Published April 1, 2024 | Version V1
Dataset Open

Reward perseveration is shaped by GABAA-mediated dopamine pauses: Electrophysiology Data

  • 1. ROR icon Duke University
  • 2. ROR icon Duke University School of Medicine
  • 3. ROR icon Aligning Science Across Parkinson's

Description

In vivo electrophysiological data, slice electrophysiological data, and HTP vs tyrosine hydroxylase immunohistochemistry data. These data were used to generate the following figures in the paper "Reward perseveration is shaped by GABAA-mediated dopamine pauses":

  • Figure 1, panels c-f
  • Ext. Fig 1, all panels
  • Ext. Fig 2, all panels

Specifics of the data:

  • Slice_Ephys .csv files contain the summarized in vitro electrophysiology data.
  • HTP_Mouse_*.7z and ddHTP_Mouse_*.7z are zipped folders with the raw data, sorted data, and extracted cells for each recording, grouped by mouse the recordings were obtained from.
  • HTP final_grouped spiking analysis_n39.mat is the MATLAB data file with all the extracted firing metrics for all 39 +HTP cells.
  • ddHTP final_grouped spiking analysis_n18.mat is the MATLAB data file with all the extracted firing metrics for all 18 ddHTP cells.
  •  Ephys_Summary_Data .csv files contain the summarized in vivo electrophysiology data.
  • VHist4_HTP and TH.7z contains the raw histological images, drawn ROIs, and ilastik cell counting performed to compare tyrosine hydroxylase and HTP expression.

Files

Ephys_Summary_Data_ddHTP all time points.csv

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Additional details

Funding

Aligning Science Across Parkinson's
Circuit Mechanisms for Dopamine Neuron Vulnerability and Resilience in PD ASAP-020607

Software

Repository URL
https://github.com/tadrosslab/VTA_GABA_paper
Programming language
MATLAB