Ext. Fig.1a: eIPSCs amplitude and gabazine.7 DART.2,,,,,,,,,,,,,,,,,,,,,,,,,,,, Y=normalized eIPSCs amplitude (mean with SE),,,,,,,,,,,,,,,,,,,,,,,,,,,, X=Time,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,Cell #1,Cell #2,Cell #3,Cell #4,Cell #5,Cell #6,Cell #7,Cell #8,Cell #9,Cell #10,,,,,,,,,,,,,,,, ,,,+HTP,+HTP,+HTP,+HTP,+HTP,+HTP,+HTP,+HTP,+HTP,+HTP,,,,,,,,,,,,,,,, ,Animal ,,"SS64, F","SS64, F","SS66, F","SS66,F","SS67, M","SS71,M","SS71,M","SS71,M","STH 6,F","STH 6,F",,,,,,,,,,,,,,,, ,DOB,,"1/11/2021,F",1/11/2021,2/25/2021,2/25/2021,4/10/2021,4/6/2021,4/6/2021,4/6/2021,4/6/2021,4/6/2021,,,,,,,,,,,,,,,, ,Surgery ,,4/22/2021,4/22/2021,6/1/20221,6/1/20221,6/23/2021,7/6/2021,7/6/2021,7/6/2021,6/24/2021,6/24/2021,,,,,,,,,,,,,,,, ,Recoding day,,4/21/2021,4/21/2021,6/30/2021,6/30/2021,7/20/2021,8/6/2021,8/6/2021,8/6/2021,8/18/2021,8/18/2021,,,Average (Y),SD,SE,,,,,,,,,,, ,"Time (min, X)",,,,,,,,,,,,,,,,,,,,,,,,,,, ,0.5,,1.078389182,1.05029307,1.028209376,1.005601487,1.094331047,1.032351589,1.0099627,1.099499302,0.99596196,1.027500301,,,1.042210001,0.035215722,0.011136189,,,,,,,,,,, ,1,,1.001222704,1.103936973,1.00264803,0.97717822,0.999622453,1.05073657,0.981702683,1.027396839,1.042242506,1.057797164,,,1.024448414,0.037602723,0.011891025,,,,,,,,,,, ,1.5,,1.155876798,1.070627844,1.004510115,1.050462306,0.904448469,1.090299187,1.044199774,0.973964918,1.062876648,0.954424952,,,1.031169101,0.069342315,0.021927965,,,,,,,,,,, ,2,,0.969610678,1.036866012,1.039889726,1.038647816,0.98861521,0.956670536,0.967261184,1.028914786,1.027576547,0.988489869,,,1.004254236,0.031613877,0.009997186,,,,,,,,,,, ,2.5,,0.96509967,1.01551698,1.028209376,1.033339856,1.004925814,1.034911523,1.036332244,0.991725095,1.004163474,0.912600626,,,1.002682466,0.036853409,0.011654071,,,,,,,,,,, ,3,,0.99532095,1.030265734,1.00264803,1.005601487,0.988617455,1.016526542,0.990052654,0.907934545,1.030923958,1.023877516,,,0.999176887,0.033872755,0.010711506,,,,,,,,,,, ,3.5,,0.924270088,0.982805421,1.004510115,0.97717822,1.062121503,1.018621033,1.025942948,0.954029422,0.961008118,1.013673765,,,0.992416063,0.038335597,0.01212278,,,,,,,,,,, ,4,,1.131583966,1.049125043,0.990121277,0.956802505,0.973915765,1.055158274,1.041526892,0.992484068,0.986102059,0.921784355,,,1.00986042,0.057038214,0.018037067,,,,,,,,,,, ,4.5,,1.10489304,0.955707195,0.988089912,0.949268627,0.971561691,1.013966608,1.023345624,0.948463618,0.93667205,1.050398767,,,0.994236713,0.05109115,0.01615644,,,,,,,,,,, ,5,,0.967052112,1.003647324,0.958973677,0.973068832,0.960854256,1.014199329,1.005872718,1.051521767,0.966084739,1.088465444,,,0.99897402,0.041104937,0.012998522,,,,,,,,,,, ,5.5,,0.97341725,0.980406038,0.960497201,1.082652512,0.943145062,0.964396976,0.988399812,0.918357677,0.966268164,0.958879597,,,0.973642029,0.040821398,0.012908859,,,,,,,,,,, ,6,,0.916380233,0.894321999,1.001124506,0.984883323,1.112937508,0.963000648,0.955106841,1.04675501,0.997104886,0.984364925,,,0.985597988,0.059070975,0.018679883,,,,,,,,,,, ,6.5,,0.890678924,0.956159999,1.020083915,0.970158016,1.041084871,0.929488784,0.996314283,0.999829311,1.047546917,0.990459928,,,0.984180495,0.046572006,0.014727361,,,,,,,,,,, gabazine.7 DART.2,7,,0.926204405,0.87032037,0.970484747,0.995156793,0.953818896,0.859672401,0.933979642,1.059123643,0.975467973,1.02728279,,,0.957151166,0.059851458,0.018926693,,,,,,,,,,, ,7.5,,0.805239294,0.839220138,0.959142957,1.002690671,0.930544538,0.770772872,0.982507287,1.088337638,0.77581108,1.007759759,,,0.916202623,0.105374564,0.033322363,,,,,,,,,,, ,8,,0.833321064,0.873905487,0.972516112,0.997553936,1.043358357,0.725857666,0.934339395,1.150703485,0.912009119,1.002452741,,,0.944601736,0.112052933,0.035434249,,,,,,,,,,, ,8.5,,0.86245471,0.817291845,0.982503658,0.962795362,0.943205524,0.6956039,0.996360751,1.150450595,1.028768612,1.08030792,,,0.951974288,0.125193775,0.039589748,,,,,,,,,,, ,9,,0.845685972,0.775155133,0.960835762,0.897045154,0.915444571,0.652085021,0.938513625,1.019431061,0.964177973,0.967649997,,,0.893602427,0.10391317,0.03286023,,,,,,,,,,, ,9.5,,0.802814503,0.86611017,0.904634657,0.822220048,0.844867352,0.63742358,0.904748509,1.026224782,0.921319937,0.965629879,,,0.869599342,0.100062876,0.03164266,,,,,,,,,,, ,10,,0.760349135,0.935686462,0.882602401,0.767256984,0.982184046,0.565279984,0.955438732,0.959726376,0.945220023,0.829187448,,,0.858293159,0.12401465,0.039216876,,,,,,,,,,, ,10.5,,0.811515479,0.856902416,0.874054484,0.729930043,0.905591906,0.528510022,0.913170449,1.080789598,0.939483409,1.068174354,,,0.870812216,0.152151428,0.048114506,,,,,,,,,,, ,11,,0.779778445,0.705023992,0.850865366,0.699623306,0.93486106,0.495929043,0.860754847,0.809318515,0.923320406,1.014996495,,,0.807447148,0.140496823,0.044428997,,,,,,,,,,, ,11.5,,0.849474616,0.854367472,0.822905791,0.682843305,0.962322205,0.452177443,0.829821569,0.805523649,0.815798868,0.889378741,,,0.796461366,0.132670922,0.041954229,,,,,,,,,,, ,12,,0.874400661,0.781338973,0.692695549,0.659385549,0.846071338,0.412847547,0.661618872,0.760744225,0.923206312,0.922374264,,,0.753468329,0.147774692,0.046730461,,,,,,,,,,, ,12.5,,0.719505566,0.561429705,0.678475992,0.664351059,0.883615424,0.398186107,0.623130215,0.730891275,0.969034165,0.917541725,,,0.714616123,0.164485039,0.052014737,,,,,,,,,,, ,13,,0.562150216,0.37942859,0.650883281,0.750648207,0.96510591,0.38794637,0.55473342,0.762515162,0.858938557,0.837326518,,,0.670967623,0.188442742,0.059590827,,,,,,,,,,, ,13.5,,0.225990336,0.361050098,0.745680326,0.696398121,0.996534361,0.381430175,0.506836359,0.682822967,0.866803858,0.791449638,,,0.625499624,0.234388987,0.074120306,,,,,,,,,,, ,14,,0.391966524,0.338006977,0.647802309,0.415151367,0.9426237,0.380033847,0.470710653,0.633995686,0.846040403,0.712344069,,,0.577867553,0.200069617,0.063267568,,,,,,,,,,, ,14.5,,0.397430702,0.354719642,0.691341306,0.233242048,0.856678059,0.349314638,0.456307453,0.584197171,0.940743115,0.739426421,,,0.560340055,0.226603606,0.071658352,,,,,,,,,,, ,15,,0.476273995,0.288901621,0.673059018,0.14871204,0.888158163,0.329300608,0.36760171,0.444879377,0.713149289,0.525246302,,,0.485528212,0.210434409,0.066545203,,,,,,,,,,, ,15.5,,0.410393755,0.268182898,0.511301336,0.068661024,0.815880041,0.333722313,0.335999267,0.394111325,0.649935781,0.577917683,,,0.436610542,0.200463531,0.063392134,,,,,,,,,,, ,16,,0.361137839,0.126980091,0.234967917,0.072085514,0.740979649,0.332791427,0.332221341,0.354642589,0.586351543,0.528522945,,,0.367068086,0.194589035,0.061534456,,,,,,,,,,, ,16.5,,0.345043368,0.205253056,0.139886548,0.066435106,0.851692473,0.325577068,0.332693582,0.30889001,0.542177452,0.546494202,,,0.366414287,0.217407952,0.068750431,,,,,,,,,,, ,17,,0.483504039,0.248102639,0.088533669,0.032190206,0.822293411,0.319991757,0.31805412,0.320740568,0.498243783,0.531357353,,,0.366301154,0.218087541,0.068965336,,,,,,,,,,, ,17.5,,0.352304566,0.273399252,0.082046842,0.090406536,0.83134503,0.296719629,0.302942417,0.258430404,0.41167206,0.502470724,,,0.340173746,0.204028699,0.06451954,,,,,,,,,,, ,18,,0.332693311,0.156477399,0.088533669,0.055476738,0.751266522,0.292763368,0.289719677,0.251220158,0.406509844,0.461944983,,,0.308660567,0.192139714,0.060759912,,,,,,,,,,, ,18.5,,0.103367521,0.215219302,0.069404979,0.069859596,0.841873063,0.276705599,0.282163826,0.240468036,0.404480827,0.398338085,,,0.290188084,0.216713147,0.068530714,,,,,,,,,,, ,19,,0.172136429,0.038723471,0.066019371,0.075510004,0.692790836,0.262044159,0.261857475,0.230727879,0.33140334,0.382562004,,,0.251377497,0.183274972,0.057956635,,,,,,,,,,, ,19.5,,0.025701702,0.189923389,0.07363699,0.02893694,0.80078681,0.042820715,0.26492704,0.239582568,0.317819455,0.360292954,,,0.234442856,0.222453632,0.070346015,,,,,,,,,,, ,20,,0.184010567,0.064273399,0.060263836,0.024998777,0.783026136,0.248313604,0.262801957,0.237179152,0.305796052,0.332431525,,,0.2503095,0.204897415,0.064794252,,,,,,,,,,, ,20.5,,0.238819515,0.298442551,0.053661899,0.027567144,0.742062796,0.027693832,0.223407542,0.245401363,0.36036908,0.296119189,,,0.251354491,0.199263848,0.063012761,,,,,,,,,,, ,21,,0.13512199,0.237462138,0.024714944,0.068832249,0.655134549,0.027461111,0.025973239,0.23781163,0.297060651,0.230735277,,,0.194030778,0.182259065,0.057635377,,,,,,,,,,, ,21.5,,0.352838976,0.125305735,0.062295201,0.058045105,0.581227948,0.242961014,0.024556517,0.247045805,0.226194313,0.16356229,,,0.20840329,0.157966644,0.049953439,,,,,,,,,,, end,22,,0.123398669,0.155573291,0.058571031,0.053250819,0.568638481,0.028159275,0.095307503,0.2528646,0.192431417,0.198065442,,,0.172626053,0.148702864,0.047023974,,,,,,,,,,, ,22.5,,0.0779775,0.087568709,0.049768449,0.067120004,0.559665506,0.016290489,0.07382055,0.240594532,0.187872222,0.136633599,,,0.149731156,0.150773786,0.047678858,,,,,,,,,,, ,23,,0.202271921,0.311171094,0.060602397,0.07003082,0.652075954,0.024901177,0.043635054,0.236926161,0.171372757,0.192879117,,,0.196586645,0.176149758,0.055703445,,,,,,,,,,, ,23.5,,0.137118958,0.290266962,0.068558577,0.057873881,0.609288668,0.024668455,0.023139795,0.228830446,0.193487194,0.133807252,,,0.176704019,0.167016404,0.052815224,,,,,,,,,,, ,24,,0.161567371,0.261212253,0.065172968,0.048798982,0.576821985,0.222946984,0.025500998,0.231486853,0.181525501,0.156799972,,,0.193183387,0.148986464,0.047113657,,,,,,,,,,, ,24.5,,0.132489518,0.228989715,0.050614851,0.054620615,0.504718427,0.024435734,0.046987951,0.239582568,0.141723176,0.131539736,,,0.155570229,0.136325972,0.043110057,,,,,,,,,,, ,25,,0.122277308,0.318560128,0.06212592,0.064380412,0.560623193,0.015359604,0.025264878,0.228197968,0.142315317,0.135311691,,,0.167441642,0.158075786,0.049987953,,,,,,,,,,, ,25.5,,0.152816772,0.254817343,0.047398522,0.056161636,0.534845029,0.021177636,0.025028758,0.23667317,0.141741056,0.145659815,,,0.161631974,0.147272631,0.046571695,,,,,,,,,,, ,26,,0.148930346,0.1835738,0.063480164,0.046573064,0.461307079,0.231790393,0.042737784,0.227438995,0.122589461,0.1774846,,,0.170590568,0.117337943,0.037105516,,,,,,,,,,, ,26.5,,0.112241663,0.139241623,0.053154057,0.044860819,0.487027199,0.039562617,0.02007023,0.198851001,0.142106328,0.166505355,,,0.140362089,0.12900875,0.040796149,,,,,,,,,,, ,27,,0.098022624,0.176591062,0.056539666,0.055134289,0.489101589,0.028391996,0.042652817,0.213018503,0.12630678,0.138159644,,,0.142391897,0.129049968,0.040809183,,,,,,,,,,, ,27.5,,0.139766243,0.244841542,0.048244925,0.057360207,0.356839495,0.205260167,0.02644548,0.218837298,0.123785106,0.138508988,,,0.155988945,0.097127246,0.030714332,,,,,,,,,,, ,28,,0.114184882,0.232790605,0.051461253,0.05136735,0.493086862,0.022108521,0.039658911,0.198724506,0.133481998,0.138333144,,,0.147519803,0.13286715,0.042016282,,,,,,,,,,, ,28.5,,0.16459873,0.164346687,0.054677581,0.052052248,0.517482027,0.028159275,0.043691537,0.221367209,0.132374658,0.121552551,,,0.15003025,0.136565716,0.043185871,,,,,,,,,,, ,29,,0.189424751,0.109481408,0.050614851,0.060099799,0.492558677,0.027693832,0.027626082,0.231486853,0.122589461,0.115731976,,,0.142730769,0.132843317,0.042008745,,,,,,,,,,, ,29.5,,0.177942998,0.250208089,0.059586714,0.052394697,0.41671878,0.026762947,0.023848156,0.206314239,0.142106328,0.12743857,,,0.148332152,0.115965167,0.036671406,,,,,,,,,,, ,30,,0.077031379,0.2926782,0.05433902,0.033560002,0.423955394,0.067396914,0.039811722,0.203784328,0.12630678,0.127918963,,,0.14467827,0.120857584,0.038218524,,,,,,,,,,, ,30.5,,0.104952993,0.248422833,0.048583485,0.055990411,0.460076273,0.06646657,0.02007023,0.177726245,0.123785106,0.121471818,,,0.142754597,0.123527785,0.039062916,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,,,, ,,,Cell #1,Cell #2,Cell #3,Cell #4,Cell #5,Cell #6,Cell #7,Cell #8,,,,,,,,,,,,,,,,,, ,,,ddHTP,ddHTP,ddHTP,ddHTP,ddHTP,ddHTP,ddHTP,ddHTP,,,,,,,,,,,,,,,,,, ,Animal ,,"SS57, F","SS57, F","SS57, F","SS57, F","SS58, F","SS58, F","SS72, M","SS72, M",,,,,,,,,,,,,,,,,, ,DOB,,12/14/2020,12/14/2020,12/14/2020,12/14/2020,12/14/2020,12/1420,"4/6/2021,M","4/6/2021,M",,,,,,,,,,,,,,,,,, ,Surgery ,,3/19/2021,3/19/2021,3/19/2021,3/19/2021,3/19/2021,3/19/2021,7/9/2021,7/9/2021,,,,,,,,,,,,,,,,,, ,Recording day,,7/20/2021,7/20/2021,7/20/2021,7/20/2021,7/22/2021,7/22/2021,8/12/2021,8/12/2021,,,,,Average (Y),SD,SE,,,,,,,,,,, ,"Time (min, X)",,,,,,,,,,,,,,,,,,,,,,,,,,, ,0.5,,1.015277642,0.949075125,1.056597567,0.963917107,1.099774763,1.018970599,1.029843354,1.004183264,,,,,1.017204928,0.044981865,0.015903491,,,,,,,,,,, ,1,,1.021104691,1.030829106,0.896146876,1.024181745,1.018174171,1.075014273,1.011895842,1.003377015,,,,,1.010090465,0.047515638,0.016799315,,,,,,,,,,, ,1.5,,0.997453726,1.028608175,1.055369401,1.14846715,1.098701019,1.068027956,1.013645734,1.01708325,,,,,1.053419551,0.047370516,0.016748006,,,,,,,,,,, ,2,,0.973802762,0.996613067,0.957657367,0.953188739,0.954598809,1.008993651,0.990261895,1.008416072,,,,,0.980441545,0.022162776,0.007835724,,,,,,,,,,, ,2.5,,0.987513466,1.015599867,0.910208158,0.898146705,1.089142687,1.019093211,0.970783096,1.002772328,,,,,0.98665744,0.0576455,0.020380762,,,,,,,,,,, ,3,,0.96112036,1.027339072,0.978241343,0.950032475,1.031270608,0.94480547,1.017805448,0.987655157,,,,,0.987283742,0.032460234,0.011476426,,,,,,,,,,, ,3.5,,1.000881402,0.992807978,0.986809835,0.994243817,0.980087601,0.985889856,1.037904519,1.00740826,,,,,0.998254159,0.017038439,0.006023998,,,,,,,,,,, ,4,,1.000538635,1.024800865,1.027363664,0.92404961,0.898188759,0.920610813,0.979539998,0.992155478,,,,,0.970905978,0.046783047,0.016540305,,,,,,,,,,, ,4.5,,0.972431691,1.004177938,0.995442803,1.006276972,1.10498698,0.997080202,0.977420657,0.962958941,,,,,1.002597023,0.041376831,0.014628919,,,,,,,,,,, ,5,,0.985799628,0.99719787,0.89234817,0.925095128,1.014853093,1.044151984,1.027032041,1.015503404,,,,,0.987747665,0.049179899,0.01738772,,,,,,,,,,, ,5.5,,1.064636177,0.992438733,1.053170646,1.071501487,0.920750917,0.996453006,0.980669531,1.006633132,,,,,1.010781704,0.047375219,0.016749669,,,,,,,,,,, ,6,,1.015620409,0.986727768,1.097001552,1.062652751,0.959070772,0.988224039,1.019153762,1.009625445,,,,,1.017259562,0.041299317,0.014601513,,,,,,,,,,, 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,21.5,,0.954950544,0.895035059,1.269457733,1.241638548,1.109843287,1.154673584,0.935659974,0.859461549,,,,,1.052590035,0.150747395,0.053297253,,,,,,,,,,, end,22,,0.994368818,0.866480236,1.258397598,1.226354367,1.100173791,1.140459915,0.925154318,0.848778748,,,,,1.045020974,0.149115421,0.052720263,,,,,,,,,,, ,22.5,,1.003280776,0.878536717,1.233409885,1.17165309,1.078327892,1.089589942,0.940912802,0.864500606,,,,,1.032526464,0.125627566,0.044416052,,,,,,,,,,, ,23,,1.012192733,0.855375583,1.219072673,1.207852465,1.06579336,1.123253895,0.929312807,0.859259987,,,,,1.034014188,0.135706193,0.047979385,,,,,,,,,,, ,23.5,,1.023161297,0.866797512,1.214157057,1.199808159,1.061495806,1.115773016,0.923403376,0.846360001,,,,,1.031369528,0.133627717,0.047244532,,,,,,,,,,, ,24,,1.031044952,0.855375583,1.211699249,1.178892965,1.059347029,1.096322733,0.916180737,0.847569375,,,,,1.024554078,0.130832411,0.046256242,,,,,,,,,,, ,24.5,,1.020761923,0.868701167,1.210060711,1.177686319,1.057914511,1.095200601,0.904580742,0.838700634,,,,,1.021700826,0.130929623,0.046290612,,,,,,,,,,, ,25,,1.023846832,0.843636378,1.186711537,1.190154993,1.03750113,1.106795962,0.916399605,0.833056891,,,,,1.017262916,0.132912117,0.04699153,,,,,,,,,,, ,25.5,,0.999167564,0.832214449,1.144519169,1.100863202,1.000613793,1.023758212,0.894950558,0.828420958,,,,,0.978063488,0.109773493,0.038810791,,,,,,,,,,, ,26,,1.006022916,0.800804144,1.124447072,1.085981237,0.983065448,1.009918587,0.900641121,0.823180339,,,,,0.966757608,0.10913134,0.038583755,,,,,,,,,,, ,26.5,,1.000538635,0.881924144,1.084712513,1.06868598,0.948326888,0.993834698,0.9028298,0.816528784,,,,,0.96217268,0.086747319,0.030669809,,,,,,,,,,, ,27,,0.999167564,0.803976458,1.063001877,1.052999585,0.929346025,0.979246985,0.880067545,0.797985054,,,,,0.938223887,0.097011799,0.03429885,,,,,,,,,,, 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,30.5,,1.107824895,0.924224434,1.147796246,1.142291375,1.003478829,1.062284736,0.902944486,0.775410079,,,,,1.008281885,0.123825426,0.043778899,,,,,,,,,,, ,,,,,,,,,,,,,,,,,,,,,,,,,,,,