Determining how Vitamin D Affects the Microenvironment of Tumors and Skin Malignancies: A Review

Abstract

As the fourth most frequent disease worldwide and the cause of 6.2% of all cancer cases combined, skin cancer poses a serious health risk. Though skin cancer death rates are lower than those of other cancers, they are noticeably higher in the Asian population (43%). The prognosis of skin cancer is associated with genetic, environmental, and DNA abnormalities; nonetheless, prolonged exposure to ultraviolet (UV) radiation continues to be one of the major contributing factors globally. In addition to being a vital source of vitamin D, exposure to the sun poses a significant environmental risk for skin cancer. However, research examining the connection between vitamin D levels and the risk of skin cancer has produced inconsistent, if not contradictory, findings. To shed light on the relationships, this study examines the function of vitamin D and skin carcinogenesis. Moreover, it has been shown that vitamin D controls the development and metastasis of tumors in addition to inhibiting cancer stem cells. In summary, to fully comprehend the complex mechanisms behind the function of vitamin D in skin carcinogenesis, well-designed studies on the metabolism of vitamin D from a genotypic and phenotypic perspective must be included. These new discoveries will create new avenues for addressing the illness and present fresh possibilities for its remediation.

Keywords: Skin Cancer, DNA, Vitamin D, Remediation.