DEVELOPMENT AND EVALUATION OF SOLID DISPERSION MATRIX TABLET COMPRISING NIFEDIPINE WITH WATER SOLUBLE POLYMERS

The basic   aim of the present investigation is to formulate and evaluate solid dispersion matrix tablet dosage form which gives better utilisation of drug. In the present investigation, efforts were made to develop solid dispersion matrix tablets of Nifedipine, which will provide similar in-vitro release profiles to that of in-house specification drug release profiles which can be confirmed by calculating fl (difference/dissimilarity factor) and f2 (similarity factor). Nifedipine has a biological half life of 2-5 hours and it requires to be administered 2-3 times a day. In principle, drug candidate should have biological half life 2 to 8 hours to develop into sustained release dosage form. As Nifedipine is antihypertensive agent, a steady state concentration is necessary to maintain its optimal therapeutic activity. Thus, this solid dispersion matrix tablet maintaining steady state concentration for a prolonged period and will be a suitable candidate. The biopharmaceutical and physicochemical properties suggest that Nifedipine is suitable candidate to develop into solid dispersion matrix tablets.

Keywords: Solid dispersion Matrix Tablet, Nifedipine, In-vitro release profiles, Biological half life.