Lewy pathology induced molecular dysfunction
Creators
Description
Probe_Data_Mouse.RDS- The pre-qc data for the mouse GeoMx experiment
Probe_Data_Hu.RDS- The probe data for the Human GeoMx experiment
ACA_Profile.csv- Reference matrix of Anterior Cingulate Area for deconvolution calculation
MOs_Profile.csv- Reference Matrix of Secondary Motor Cortex for deconvolution calculation
Profile_human_allreg.csv_profileMatrix- Human reference matrix for deconvolution claculation
Profile_Matrix_setup_Human- Code for Human Profile Matrix setup
Profile_Matrix_Setup_Mu- Code for Mouse profile matrix setup
Top_genesets_mu/hu- The top differential genesetsets in the mouse/human data
LAMDA_Signature_Mouse- Data for the LAMDA signature for Mouse. (Differentially epxressed genes between Aggregate bearing and Non-aggregate bearing neurons). Avilable as CSV and RDS. Use this to explore the LAMDA signature for your genes of interest
LAMDA_Signature_Human-Data for the LAMDA signature for Human. (Differentially epxressed genes between Aggregate bearing and Non-aggregate bearing neurons). Avilable as CSV and RDS. Use this to explore the LAMDA signature for your genes of interest
Anchors-3mon: Anchors for cosmx cell typing
asstats_3mon: stats for cosmx cell typing
cohort_3mon: cohort info for cosmx cell typing
pSyn_positive_cells: CSV identifying all psyn postive cells
seurat_object_3mon: Seurat object contianing all the CosMx data (Note: CosMx method does not use Fastq files)
Files
ACA_Profile_.csv
Files
(195.7 MB)
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Additional details
Related works
- Is supplement to
- Computational notebook: 10.5281/zenodo.10732492 (DOI)