SPINA Thyr
Contributors
- 1. Ludwig-Maximilian University of Munich
- 2. Klinikum Lüdenscheid
- 3. North Lakes Clinical
Description
Structure parameter inference approach for endocrine feedback control
SPINA is software for determining constant structure parameters of endocrine feedback control systems from hormone levels obtained in vivo.
The first version of this cybernetic approach allows for evaluating the functional status of the thyroid gland, i.e. thyroid's secretory capacity (GT or SPINA-GT) and sum activity of peripheral deiodinases (GD or SPINA-GD). The software additionally provides means to calculate Jostel's TSH index (JTI) and the thyrotroph thyroid hormone sensitivity index (TTSI), two parameters for the assessment of the anterior pituitary function and the location of the set point of thyroid homeostasis.
A second version (provided elsewhere) has been developed for insulin-glucose homeostasis. It delivers the secretory capacity of pancreatic beta cells (SPINA-GBeta), an estimate for the insulin receptor gain (SPINA-GR) and a static disposition index as a measure for the loop gain of the feedback loop (SPINA-DI).
Both implementations of SPINA have been validated in clinical studies based on large cohorts.
Files
SPINA Thyr 4.2.1 for Linux.zip
Files
(54.8 MB)
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Additional details
Identifiers
Related works
- Is cited by
- Journal article: 10.3389/fendo.2016.00057 (DOI)
- Is part of
- Software: http://spina.sf.net (URL)
Dates
- Updated
-
2024-02-24
Software
- Repository URL
- https://svn.code.sf.net/p/spina/code/
- Programming language
- Pascal
- Development Status
- Active
References
- Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH, Midgley JE, Hoermann R. Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research. Front Endocrinol (Lausanne). 2016 Jun 9;7:57. doi: 10.3389/fendo.2016.00057. eCollection 2016. PubMed PMID: 27375554; PubMed Central PMCID: PMC4899439.