Published November 28, 2017
| Version 1.0
Software
Open
chemotherapy_smac_mimetics_in_CRC_model: Version 1.0
Creators
- 1. Cell Death & Drug Resistance Group, Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, UK;
- 2. Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland;
- 3. Institute of Cell Biology and Immunology, University of Stuttgart, D-70569 Stuttgart, Germany; Stuttgart Research Centre Systems Biology, University of Stuttgart, D-70569 Stuttgart, Germany;
- 4. Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland;
- 5. Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland;
- 6. Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Institute of Cell Biology and Immunology, University of Stuttgart, D-70569 Stuttgart, Germany; Stuttgart Research Centre Systems Biology, University of Stuttgart, D-70569 Stuttgart, Germany;
Description
MATLAB code and experimental datasets for "Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711".
Output files from the simulations are also provided as MATLAB .mat files in simulation_outputs.zip for convenience.
Notes
Christian T Hellwig and Frank A Lincoln received support from the Irish Research Council (GOIPD/2013/102; GOIPG/2014/1299). Markus Rehm receives further support from the German Research Foundation (FOR2036, MO 3226/1-1).
Files
manuela_s-chemotherapy_smac_mimetics_in_crc_model-2f2361cf8a25.zip
Files
(306.6 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:39c047ec53bc64a79ca9ee7802ae3bcf
|
122.3 kB | Preview Download |
|
md5:b0b2001cfe65f43cca053d03e63b5728
|
306.5 MB | Preview Download |
Additional details
Related works
Funding
- Development of personalised medicine approaches for the clinical application of IAP antagonists in metastatic and high risk early stage colorectal cancer 14/IA/2582
- Science Foundation Ireland
- APO-DECIDE – Apoptosis Modelling for Treatment Decisions in Colorectal Cancer 306021
- European Commission
- BCL-2 family proteins and cellular bioenergetics in the control of cell survival: Towards novel predictive and prognostic markers for disease progression and therapy responses in colorectal cancer patients 13/IA/1881
- Science Foundation Ireland