Published February 13, 2024 | Version v1
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Data of study "Lateral septum neurons that disable sociability in an autism mouse model

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Data of study  "Lateral septum neurons that disable sociability in an autism mouse model"
 
Authors: Borie and colleagues
contact information
freddy.jeanneteau@igf.cnrs.fr
Orcid 0000-0002-9606-2892
institut de genomique fonctionnelle
141 rue de la Cardonille 
34090 Montpellier
France
 
 
Description of data presented by main figures
 
***Calcium activity in SST neurons of LS during social behavor Figure 1D***
data of photometry
 
 
***Area under spikes of knockout model Figure 1E***
data of in vivo photometry
 
 
***Spike duration of knockout model Figure 1F***
data of in vivo photometry
 
 
***Proportion of SST neurons in LS expressing c-FOS in Magel2 KO mice Figure 1G***
data of histology
 
 
***Optogenetic inhibition of SST neurons in LS of knockout model restored social discrimination Figure 1I***
data of mouse behavior
 
 
*** Injection of SSTR antagonist in LS of knockout model restored social discrimination Figure 1K***
data of mouse behavior
 
 
***Injection of SST in LS of WT mice restored social discrimination Figure 1L***
data of mouse behavior
 
 
***Proportion of SST neurons in LS expressing OXTR in Magel2 KO mice Figure 2B***
data of histology
 
 
***Density of SST neurons in LS of Magel2 KO mice Figure 2C***
data of histology
 
 
***Frequency of action potential in LS neurons inhibited by AVP then TGOT in WT mice Figure 2E***
data of electrophysiology ex vivo
 
 
***Frequency of action potential in LS neurons inhibited by AVP and TGOT in Magel2KO mice Figure 2F***
data of electrophysiology ex vivo
 
 
***Proportion of SST neurons insensitive to AVP and TGOT Figure 2G***
data of histology
 
 
***Frequency of action potential in LS neurons inhibited by AVP with GABAzine  Figure 2J***
data of electrophysiology ex vivo
 
 
***Frequency of action potential in LS neurons inhibited by TGOT  with GABAzine Figure 2K***
data of electrophysiology ex vivo
 
 
***Pharmacological inhibition of AVPR and OXTR during social novelty in Magel2 WT mice Figure 3A***
data of mouse behavior
 
 
***Effect of inhibitors injected during social novelty on the proportion of SST neurons with cFOS after social discrimination Figure 3C***
data of histology
 
 
***Pharmacological inhibition of AVPR and OXTR during social habituation in Magel2 WT mice Figure 3D***
data of mouse behavior
 
 
***Effect of inhibitors injected during social habituation on the proportion of SST neurons with cFOS after social discrimination Figure 3F***
data of histology
 
 
***Co-injection of AVP with antagonist of AVPR and OXTR in Magel2 KO mice Figure 3G***
data of mouse behavior
 
 
***Area under spikes in OXT neurons of PVN of WT mice Figure 4C***
data of in vivo photometry
 
 
***Proportion of OXT neurons in PVN expressing c-FOS in Magel2 KO mice Figure 4E***
data of histology
 
 
***Area under spikes in AVP neurons of PVN of WT mice Figure 4H***
data of in vivo photometry
 
 
***Proportion of AVP neurons in PVN expressing c-FOS in Magel2 KO mice Figure 4J***
data of histology
 
 
***Optogenetic inhibition of oxytocinergic or vasopressinergic PVN-LS pathways in Avp-CRE or OXT-Cre mice Figure 5B***
data of mouse behavior
 
 
***Optogenetic inhibition of oxytocinergic or vasopressinergic SON-LS pathways in Avp-CRE or OXT-Cre mice Figure 5D***
data of mouse behavior
 
 
***Optogenetic activation of oxytocinergic or vasopressinergic PVN-LS pathways in Magel2 KO;Avp-CRE or Magel2 KO;OXT-Cre double transgenic mice Figure 5F***
data of mouse behavior
 
 
***Optogenetic activation of oxytocinergic or vasopressinergic SON-LS pathways in Magel2 KO;Avp-CRE or Magel2 KO;OXT-Cre double transgenic mice Figure 5H***
data of mouse behavior

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