Baltic Biomaterials Centre of Excellence

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Published May 17, 2022 | Version v1
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Bioaccumulation of lead (Pb) and its effects on human: A review

Authors/Creators

  • 1. Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India
  • 2. Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 602105, Tamil Nadu, India
  • 3. Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka St 3, Riga, LV-1007, Latvia
  • 4. Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Kalku Street 1, LV-1658 Riga, Latvia
  • 5. National University of Science and Technology "MISIS ", Leninskiy Pr. 4, 119049 Moscow, Russia
  • 6. Universidad de Buenos Aires (UBA), Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Junín 956, C1113AAD Buenos Aires, Argentina

Description

Lead is a prevalent heavy metal that pollutes the environment and accumulates in the human body via absorption, bioavailability, bioconcentration, and biomagnification disrupts the neurological, skeletal, reproductive, hematopoietic, renal, and cardiovascular systems. Lead's distinctive physical and chemical characteristics make it ideal for a variety of uses. It has been linked to human activities for ages and is harmful to health. This review article examines the long-term health consequences of lead exposure in humans. Acute and chronic symptoms of lead poisoning include kidney, brain, reproductive organ, and CNS/PNS damage. Toxic metals have a long half-life in the bone matrix and brain (2–3 years), causing neurological problems and bone loss. The article also shows the problems of high BPb in both men and women during pregnancy. Renal system blood lead levels of 30–60 g/dL may cause kidney failure in severe circumstances. The oxidative stress that occurs in human cells has also been explored. Finally, lead poisoning and lead buildup prevention and therapy have been reviewed. The use of micronutrients and antioxidants has demonstrated a reduction in harmful effects. Adults with BPb >45 g/dL should have chelation, whereas children should receive succimer.

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Bioaccumulation of lead (Pb) and its effects on human A review.pdf

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Additional details

Identifiers

ISSN
2772-4166

Related works

Is published in
Publication: 10.1016/j.hazadv.2022.100094 (DOI)

Funding

European Commission
BBCE - Baltic Biomaterials Centre of Excellence 857287

Dates

Accepted
2022-05-17