FORMULATION AND EVALUATION OF EXTENDED-RELEASE TABLETS OF AZILSARTAN USING DIFFERENT POLYMERS

The objective of the present work was to Formulate and evaluate of extended release tablets of Azilsartan by using different polymers like HPMC K100M ,Ethyl cellulose and Xanthan gum with different ratios by using direct compression method. Azilsartan is used alone or together with other medicines to treat high blood pressure (hypertension). The tablets were formulated to reduce the frequency of dose admimistration and to improve the patient compliance. The FTIR studies indicates there is no interaction between drug and polymer for optimized formulation.  The pre compression and post compression parameters are with in the IP limits. The in vitro dissolution study was done for 12hrs Among all the formulations A6 formulation was shows good drug release of 99.87%. The optimized formulation were fitted to zero order, First order, higuchi release model and korsmeyer –peppas model based on the regression coefficient.

Keywords: Azilsartan, HPMC K100M ,Ethyl cellulose and Xanthan Extended release tablets.