Impact Of Antisolvent Crystallization On Rate Of Dissolution Of Nifedipine

Aim of the present study was to study the effect of the antisolvent method of crystallization/precipitation on the rate of dissolution using different antisolvent for nifedipine. Recrystallization of the drug was done in DMF, DMSO and ethanol using water as antisolvent. Drug Excipient Compatibility Study was confirmed by FTIR method. Differential scanning calorimetry (DSC) of pure drug and it’s solvates were done to confirm the crystalline structure of the and molecular symmetry was assured by XRD studies. Impact of the size of drug and it’s solvates n dissolution was confirmed by SEM. Dissolution of pure drug and it’s solvates were performed by using USP II apparatus and it was observed that DMF solvate has the maximum dissolution amongst all solvates and pure drug. So, it is concluded that the antisolvent process has the significant effect on the dissolution of drug. Since all the techniques (DSC, SEM and XRD) used to assert the effect of the process on the dissolution