Published January 17, 2024
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Evaluation of empagliflozin efficacy as a promising anti-aging treatment in mice: In-vivo study
Authors/Creators
- 1. Al-Mustafa University College, Baghdad, Iraq
Description
Aim: Evaluation of the anti-aging properties of Empagliflozin (EMP) associated with the aging process in mice.
Methods: The mice were allocated into four groups: negative control received normal saline without receiving D-galactose (DGA); all the three other groups received DGA (200 mg/kg/day orally) for eight weeks; the second group received normal saline; the third group received vitamin C, the final group received EMP and continued for another eight weeks.
Results: Treatment with EMP reduced the levels of TNF-α, IL-1β, and MDA levels significantly compared to induction group (91.7±9.6 ng/ml, 30.6±5.5 pg/ml, and 66.7±8.3 ng/ml vs. 304.0±102.9 ng/ml, 70.2±6.8 pg/ml, and 204.7±56.9 ng/ml; respectively), while levels of GSH-Px were significantly increased (3.3±0.6 ng/ml vs. 0.3±0.2 ng/ml). In addition, EMP increases the level of both COL-1 and COL-3 compared to the induction group (1,783.6±186.9, and 1,583.6±186.9, vs. 885.7±242.5, and 685.7±242.5 pg/ml; respectively).
Conclusion: EMP positively affects several aging parameters in mice.
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