Published November 9, 2023
| Version v1
Poster
Open
In vitro model of atrial fibrillation: investigating the initiation and maintenance mechanisms of atrial remodeling using hiPSC-derived atrial cardiomyocytes
Authors/Creators
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1.
Instituto de Investigación Sanitaria La Fe
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2.
Universitat Politècnica de València
- 3. University of Freiburg
Description
Despite atrial fibrillation (AF) being a common, clinically important, and economically significant public health problem, the initiation mechanisms of atrial remodeling during AF is still unclear. Furthermore, really few experimental models have the power to investigate these mechanisms in a human invitro two-dimensional (2D) monolayer of atrial cardiomyocytes.
The purpose of this work is to use human induced pluripotent stem cell (hiPSC)-derived atrial cardiomyocytes to develop a new human in vitro atrial model of AF able to reproduce and evaluate the arrhythmia initiation and maintenance mechanisms.
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Additional details
Identifiers
Related works
- Is original form of
- 10.1093/eurheartj/ehad655.3176 (DOI)
Funding
Dates
- Available
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2023-11-09