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Published January 16, 2024 | Version v1
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Generation of KRAS knockout pancreatic cancer cell line PANC1

Creators

  • 1. Stony Brook University

Description

We used CRISPR to inactivate mutant KRAS and STAT3 in PANC1 (KRASG12D) pancreatic cancer cell line. Gene expression analysis of KRAS intact vs. knockout cells identified sets of genes involved in protein synthesis, cell differentiation, and metabolic processes, while the expression of MAPK/ERK target genes remained unperturbed.

Notes

Funding provided by: National Cancer Institute
Crossref Funder Registry ID: https://ror.org/040gcmg81
Award Number: R01AI105114

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