Systematic reconstruction of molecular pathway signatures using scalable single-cell perturbation screens

Seurat objects, differential expression analysis results, and pathway gene lists for the manuscript "Systematic reconstruction of molecular pathway signatures using scalable single-cell perturbation screens"

1. Seurat_object_IFNB_Perturb_seq.rds:  Seurat object of the Perturb-seq data for Interferon-beta pathway
2. Seurat_object_IFNG_Perturb_seq.rds:  Seurat object of the Perturb-seq data for Interferon-gamma pathway
3. Seurat_object_TNFA_Perturb_seq.rds:  Seurat object of the Perturb-seq data for TNF-alpha pathway
4. Seurat_object_TGFB1_Perturb_seq.rds: Seurat object of the Perturb-seq data for TGF-beta1 pathway
5. Seurat_object_INS_Perturb_seq.rds:   Seurat object of the Perturb-seq data for insulin pathway

6. Pathway_genelist.rds:   The pathway gene lists from MultiCCA analysis
7. Pathway_Exclusive_genelist.rds:  The pathway exclusive gene lists generated from Pathway_genelist.rds
8. HClust_Pathway_celltype_specific_genelist.rds:   The pathway gene lists from hierarchical clustering analysis independently done on each cell line

9. DE_results_all_pathway.zip:   The DE test results for all the regulators, cell lines, and pathways (from Mixscale weighted DE test)