Safety and side effects of suxamethonium in clinical practice – literature overview
Description
MAZUR, Bartosz, GREGUŁA, Anna, STACHYRAK, Karol, MIKA, Dawid, KŁOS, Aleksandra, TUREK, Kamila, LAMBACH, Maciej, PAWLICKI, Mateusz, MAZUREK, Aleksandra and WILANOWSKA, Wiktoria. Safety and side effects of suxamethonium in clinical practice – literature overview. Journal of Education, Health and Sport. 2024;52:11-24. eISSN 2391-8306. https://dx.doi.org/10.12775/JEHS.2024.52.001
https://apcz.umk.pl/JEHS/article/view/47756
https://zenodo.org/records/10488643
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 05.01.2024 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical culture sciences (Field of medical and health sciences); Health Sciences (Field of medical and health sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 05.01.2024 Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2024;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 02.01.2024. Revised: 06.01.2024. Accepted: 09.01.2024. Published: 11.01.2024.
Safety and side effects of suxamethonium in clinical practice – literature overview
1. Bartosz Mazur [BM]
Stefan Kardynał Wyszyński Province Specialist Hospital in Lublin, Kraśnicka 100 avenue, 20-718 Lublin, Poland
https://orcid.org/0000-0003-0601-4350
2. Anna Greguła [AG]
Independent Public Health Care Center in Łęczna Krasnystawska 52 street, 21-010 Łęczna, Poland
https://orcid.org/0009-0007-3712-7960
3. Karol Stachyrak [KS]
Independent Public Health Care Center in Łęczna Krasnystawska 52 street, 21-010 Łęczna, Poland
https://orcid.org/0009-0008-3175-1866
4. Dawid Mika [DM]
1st Military Clinical Hospital with SPZOZ Polyclinic in Lublin, Racławickie 23 avenue, 20-049 Lublin, Poland
https://orcid.org/0009-0003-5254-5344
5. Aleksandra Kłos [AK]
Student Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland
https://orcid.org/0009-0008-6870-2590
6. Kamila Turek [KT]
Medical University of Lublin, Racławickie 1 avenue, 20-059 Lublin, Poland
https://orcid.org/0009-0000-6888-8913
7. Maciej Lambach [ML]
Stefan Kardynał Wyszyński Province Specialist Hospital in Lublin, Kraśnicka 100 avenue, 20-718 Lublin, Poland
https://orcid.org/0009-0004-3348-4272
8. Mateusz Pawlicki [MP]
Stefan Kardynał Wyszyński Province Specialist Hospital in Lublin, Kraśnicka 100 avenue, 20-718 Lublin, Poland
https://orcid.org/0000-0001-8318-6573
9. Aleksandra Mazurek [AM]
Student Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland
https://orcid.org/0009-0007-5298-782X
10. Wiktoria Wilanowska [WW]
Stefan Kardynał Wyszyński Province Specialist Hospital in Lublin, Kraśnicka 100 avenue, 20-718 Lublin, Poland
https:/orcid.org/0009-0000-8388-8479
ABSTRACT
Keywords:
suxamethonium; succinylcholine; suxamethonium hyperkalemia; suxamethonium myalgia; suxamethonium anaphylaxis; suxamethonium cholinesterase deficiency; suxamethonium malignant hyperthermia.
Introduction and purpose
Muscle relaxants have been integral to medical practice for decades, benefiting both anesthesiologists for smooth patient intubation and surgeons requiring deep muscle relaxation. This article focuses on succinylcholine, a prominent muscle relaxant, exploring its historical context, efficacy, and the accumulated data on potential life-threatening side effects. The manuscript analyzes the available knowledge regarding the adverse effects of succinylcholine in clinical practice, presenting literature-identified methods aimed at risk mitigation. Summarizing the current understanding of succinylcholine's risks seeks to enhance its effective use, decrease adverse incidents in patients, and contribute to the overall safety of both patients and healthcare providers.
Material and methods
The following review of studies was based on articles obtained from the PubMed and Google Scholar databases. Key search terms included suxamethonium, succinylcholine, suxamethonium hyperkalemia, suxamethonium myalgia, suxamethonium anaphylaxis, suxamethonium cholinesterase deficiency, and suxamethonium malignant hyperthermia.
Conclusions
Suxamethonium's adverse effects range from muscle pain-related discomfort to rare, potentially lethal multi-organ complications, impacting patients' health diversely. Despite its drawbacks, succinylcholine remains crucial in anesthesiology. Ongoing research offers avenues to counteract or mitigate side effects. However, these methods necessitate further research to develop universal, widely available protocols in clinical settings.
Files
47756.pdf
Files
(199.6 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:d76efe9bed4a78b1c889cd4ea1ca9f0a
|
199.6 kB | Preview Download |