Biodiversity Literature Repository
Published January 31, 2019 | Version v1
Journal article Restricted

Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease

Creators

  • 1. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510006, China

Description

Xia, Chun-Li, Tang, Gui-Hua, Guo, Yan-Qiong, Xu, You-Kai, Huang, Zhi-Shu, Yin, Sheng (2019): Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease. Phytochemistry 157: 82-91, DOI: 10.1016/j.phytochem.2018.10.028, URL: http://dx.doi.org/10.1016/j.phytochem.2018.10.028

Files

Restricted

The record is publicly accessible, but files are restricted to users with access.

Linked records

Additional details

Identifiers

LSID
urn:lsid:plazi.org:pub:FFB2FFDE046BB466FFA1FF81A11CFFEA

Has part
Figure: 10.5281/zenodo.10481305 (DOI)
Figure: 10.5281/zenodo.10481307 (DOI)
Figure: 10.5281/zenodo.10481309 (DOI)
Figure: 10.5281/zenodo.10481311 (DOI)
Figure: 10.5281/zenodo.10481315 (DOI)
Figure: 10.5281/zenodo.10481317 (DOI)
Figure: 10.5281/zenodo.10481319 (DOI)
Figure: 10.5281/zenodo.10481321 (DOI)

References

  • Bachurin, S.O., Bovina, E.V., Ustyugov, A.A., 2017. Drugs in clinical trials for Alzheimer's disease: the major trends. Med. Res. Rev. 37, 1186-1225.
  • Boonsri, S., Gunawan, C., Krenske, E.H., Rizzacasa, M.A., 2012. Synthetic studies towards the mulberry Diels-Alder adducts: H-bond accelerated cycloadditions of chalcones. Org. Biomol. Chem. 10, 6010-6021.
  • Cavalli, A., Bolognesi, M.L., Minarini, A., Rosini, M., Tumiatti, V., Recanatini, M., Melchiorre, C., 2008. Multi-target-directed ligands to combat neurodegenerative diseases. J. Med. Chem. 51, 347-372.
  • Dai, S.J., Chen, R.Y., Yu, D.Q., 2006. Diels-Alder type adducts of Morus macroura Miq. J. China Pharm. Univ. 37, 119-122.
  • Di, L., Kerns, E.H., Fan, K., McConnell, O.J., Carter, G.T., 2003. High throughput artificial membrane permeability assay for blood-brain barrier. Eur. J. Med. Chem. 38, 223-232.
  • Emmerzaal, T.L., Kiliaan, A.J., Gustafson, D.R., 2015. 2003-2013: a decade of body mass index, Alzheimer's disease, and dementia. J. Alzheimers Dis. 43, 739-755.
  • Forman, M.S., Trojanowski, J.Q., Lee, V.M., 2004. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nat. Med. 10, 1055-1063.
  • Fukai, T., Hano, Y., Hirakura, K., Nomura, T., Uzawa, J.U.N., Fukushima, K., 1985. Structures of two natural hypotensive Diels-Alder type adducts, mulberrofurans F and G, from the cultivated mulberry tree (Morus lhou KOIDZ.). Chem. Pharm. Bull. 33, 3195-3204.
  • Geng, C.A., Ma, Y.B., Zhang, X.M., Yao, S.Y., Xue, D.Q., Zhang, R.P., Chen, J.J., 2012. Mulberrofuran G and isomulberrofuran G from Morus alba L.: anti-hepatitis B virus activity and mass spectrometric fragmentation. J. Agric. Food Chem. 60, 8197-8202.
  • Greig, N.H., Utsuki, T., Ingram, D.K., Wang, Y., Pepeu, G., Scali, C., Yu, Q.S., Mamczarz, J., Holloway, H.W., Giordano, T., Chen, D.M., Furukawa, K., Sambamurti, K., Brossi, A., Lahiri, D.K., 2005. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β -amyloid peptide in rodent. Proc. Natl. Acad. Sci. U.S.A. 102, 17213-17218.
  • Gunawan, C., Rizzacasa, M.A., 2010. Mulberry Diels-Alder adducts: synthesis of chalcomoracin and mulberrofuran C methyl ethers. Org. Lett. 12, 1388-1391.
  • Guo, Y.Q., Tang, G.H., Lou, L.L., Li, W., Zhang, B., Liu, B., Yin, S., 2018. Prenylated flavonoids as potent phosphodiesterase-4 inhibitors from Morus alba: isolation, modification, and structure-activity relationship study. Eur. J. Med. Chem. 144, 758-766.
  • Hano, Y., Kohno, H., Itoh, M., Nomura, T., 1985. Structures of three new 2-arylbenzofuran derivatives from the Chinese crude drug "Sang-Bai-Pi" (Morus Root Bark). Chem. Pharm. Bull. 33, 5294-5300.
  • Hirakura, K., Hano, Y., Fukai, T., Nomura, T., Uzawa, J.U.N., Fukushima, K., 1985. Structures of three new natural Diels-Alder type adducts, kuwanons P and X, and mulberrofuran J, from the cultivated mulberry tree (Morus lhou KOIDZ.). Chem. Pharm. Bull. 33, 1088-1096.
  • Jakob-Roetne, R., Jacobsen, H., 2009. Alzheimer's disease: from pathology to therapeutic approaches. Angew. Chem. Int. Ed. 48, 3030-3059.
  • LaFerla, F.M., Green, K.N., Oddo, S., 2007. Intracellular amyloid- β in Alzheimer's disease. Nat. Rev. Neurosci. 8, 499-509.
  • Lee, S., Zheng, X.Y., Krishnamoorthy, J., Savelieff, M.G., Park, H.M., Brender, J.R., Kim, J.H., Derrick, J.S., Kochi, A., Lee, H.J., Kim, C., Ramamoorthy, A., Bowers, M.T., Lim, M.H., 2014. Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease. J. Am. Chem. Soc. 136, 299-310.
  • Lewerenz, J., Maher, P., 2015. Chronic glutamate toxicity in neurodegenerative diseases-What is the evidence? Front. Neurosci. 9, 469-488.
  • Liang, J.H., Fu, Y.W., Zhang, Q.Z., Xu, D.H., Wang, B., Lin, D.J., 2015. Identification and effect of two flavonoids from root bark of Morus alba against ichthyophthirius multifiliis in grass carp. J. Agric. Food Chem. 63, 1452-1459.
  • Morphy, R., Kay, C., Rankovic, Z., 2004. From magic bullets to designed multiple ligands. Drug Discov. Today 9, 641-651.
  • Nomura, T., Fukai, T., Matsumoto, J., Ohmori, T., 1982. Constituents of the cultivated mulberry tree. Planta Med. 46, 28-32.
  • Nomura, T., Fukai, T., Narita, T., Terada, S., Uzawa, J., Iitaka, Y., Takasugi, M., Ishikawa, S.-i., Nagao, S., Masamune, T., 1981. Confirmation of the structures of kuwanons G and H (albanins F and G) by partial synthesis. Tetrahedron Lett. 22, 2195-2198.
  • Nomura, T., Hano, Y., 1994. Isoprenoid-substituted phenolic compounds of moraceous plants. Nat. Prod. Rep. 11, 205-218.
  • Nomura, T., Hano, Y., Itoh, M., 1985. Structures of kuwanols A and B, two novel stilbene derivatives from the cultivated mulberry tree (Morus bombycis Koidz.). Heterocycles 23, 819-824.
  • Pardridge, W.M., 2005. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2, 3-14.
  • Scarpini, E., Scheltens, P., Feldman, H., 2003. Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neurol. 2, 539-547.
  • Tan, Y.X., Yan, R.Y., Wang, H.Q., Chen, R.Y., Yu, D.Q., 2009. Wittiorumins A - F, antioxidant Diels-Alder-type adducts from Morus wittiorum. Planta Med. 75, 249-255.
  • Uttara, B., Singh, A.V., Zamboni, P., Mahajan, R.T., 2009. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr. Neuropharmacol. 7, 65-74.
  • Wang, Z.R., Wang, Y.L., Wang, B., Li, W.R., Huang, L., Li, X.S., 2015. Design, synthesis, and evaluation of orally available clioquinol-moracin M hybrids as multitarget-directed ligands for cognitive improvement in a rat model of neurodegeneration in Alzheimer's disease. J. Med. Chem. 58, 8616-8637.
  • Wyss-Coray, T., 2006. Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat. Med. 12, 1005-1015.
  • Xia, C.L., Wang, N., Guo, Q.L., Liu, Z.Q., Wu, J.Q., Huang, S.L., Ou, T.M., Tan, J.H., Wang, H.G., Li, D., Huang, Z.S., 2017. Design, synthesis and evaluation of 2-arylethenyl- N - methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment. Eur. J. Med. Chem. 130, 139-153.
  • Yang, Y., Tan, Y.X., Chen, R.Y., Kang, J., 2014. The latest review on the polyphenols and their bioactivities of Chinese Morus plants. J. Asian Nat. Prod. Res. 16, 690-702.

This site uses cookies. Find out more on how we use cookies