PREVALENCE OF GLOBUS SYNDROME AND ASSOCIATED FACTORS: A PROTOCOL FOR SYSTEMATIC REVIEW

Background: The feeling of globus refers to a consistent or sporadic non-painful perception of a mass or foreign object in the pharynx. The aforementioned clinical disease is often observed in medical practice, characterized by its chronic nature, resistance to treatment, and propensity for recurrence.

Methods: A comprehensive search was conducted using electronic databases, including PubMed, Embase, and Cochrane Library, to identify relevant studies published from 2000 to 2022. The search was limited to English-language studies that examined the prevalence of globus syndrome and other associated factors.

Results: The initial search identified a total of 3052 studies and 59 studies were eligible for inclusion in this systematic review. The elusive origin of globus makes the establishment of standardized inquiry and treatment approaches challenging for individuals experiencing this condition. In order to effectively manage globus, it is essential to engage in meticulous history collection and do nasolaryngoscopy as a first measure. Considering the non-malignant characteristics of the ailment and the contemporary understanding that gastroesophageal reflux disease (GERD) plays a significant role in the development of globus sensation, it is justifiable to pursue empirical treatment including the administration of proton pump inhibitors at a substantial dosage for individuals exhibiting typical globus symptoms. In cases when patients exhibit a lack of response to the treatment, it is advisable to consider doing definitive tests, including endoscopy, multichannel intraluminal impedance/pH monitoring, and manometry. In cases when patients continue to have symptoms after negative examinations, the implementation of speech and language therapy, administration of anti-depressants, and use of cognitive-behavioral therapy have shown potential efficacy.

Conclusion: Global syndrome is widespread. Research has identified this condition's causes and triggers. Reflux acid may produce globus. Upper esophageal sphincter and motor dysfunction. A full diagnosis is needed since globus syndrome is connected to pharyngeal inflammatory illnesses, upper aerodigestive tract malignancy, tongue base hypertrophy, retroverted epiglottis, thyroid disorders, cervical heterotopic gastric mucosa, and uncommon malignancies. An unknown link exists between mental health and globus, however stress may increase symptoms. Globus evaluation and treatment must involve physical and psychological factors. Many psychological and physical causes induce globus syndrome. Understanding these factors may help clinicians treat this discomfort. This sickness requires further investigation and therapy.