FORMULATION AND EVALUATION OF TOLFENAMIC ACID MOUTH DISSOLVING TABLETS USING DIFFERENT SUPERDISINTEGRANTS

The current study aimed to create and assess mouth-dissolving tablets containing Tolfenamic acid using different superdisintegrants such as Sodium starch glycolate (SSG), Crospovidone (CP), and Microcrystalline Cellulose (MCC). Variations in the concentrations of these superdisintegrants were employed to enhance the release rates. Tablets were prepared using direct compression technique, incorporating varied concentrations of different superdisintegrants. Pre-compression and post-compression assessments including Bulk density, Tapped density, Angle of repose, Cars index, Hauser’s ratio, etc., were conducted. Post-compression evaluations encompassed thickness, weight variation, hardness, friability, uniformity of drug content, and dissolution studies. The in-vitro drug release study in 0.1N NaOH for 5 minutes and in phosphate buffer pH 6.8 for 30 minutes indicated that formulations F4 and F8 exhibited the maximum drug release within 1 minute, attributed to the presence of Crospovidone, demonstrating cumulative drug releases of 99.86% and 99.97%, respectively. Consequently, these formulations were deemed optimal and subjected to stability studies over three months, during which their pre-compression and post-compression properties were re-evaluated, revealing no significant changes.