DOSING AND APPROPRIATE DURATION OF INTRAVENOUS ANTIBIOTIC FOR PEDIATRIC

The effective management of infections in pediatric patients necessitates the careful consideration of various factors, including the proper choice of antibiotics, optimal dosage, and duration of treatment. This approach aims to optimize the effectiveness of the medicines while minimizing any potential adverse effects. An essential aspect of achieving optimal dosing is a comprehensive comprehension of the pharmacokinetics and pharmacodynamics of the medications that are now accessible. The utilization of pharmacokinetic/pharmacodynamic (PK/PD) principles in dosing techniques can be advantageous in tailoring antibiotic dosages to ensure efficient eradication of bacteria in patients with modified pharmacokinetics or illnesses caused by organisms that are less sensitive or resistant. The objective of the present review is to examine the optimal duration and dose regimen for intravenous antibiotic therapy in the pediatric population.

A methodology for diluting antimicrobial agents in a healthcare facility has been developed specifically for the pediatric population. The purpose of this protocol is to ensure the proper administration of intravenous drugs in various healthcare settings, including inpatient units, emergency departments, and pediatric intensive care units (PICUs). The elements taken into account encompass the necessary diluent specifications and monitoring parameters, following a comprehensive evaluation of manufacturer labeling, primary literature, and drug information databases.