A Review On Pharmaceutical Aerosol

The effectiveness of inhaling medications isn't solely determined by the drugs themselves; it also relies on where and how much of the medication is deposited in the respiratory system. This article examines the primary factors influencing how inhaled aerosols are transported and deposited in the human lung. It discusses the deposition of aerosols in both healthy and diseased lungs, drawing mainly from human studies utilizing non-imaging methods. Additionally, it delves into how the flow pattern impacts aerosol deposition. The article briefly touches on the connection between the therapeutic effects of inhaled drugs and where they are deposited in the lungs. Research indicates that the overall deposition in the lungs is not a reliable indicator of clinical effectiveness. Instead, evaluating the distribution of deposited particles and their sizes is crucial in predicting how well a drug will work.