A Comprehensive Review and Case Studies of Transferosomal Bigels in Transdermal Applications

Abstract: This comprehensive review meticulously examines transferosomal bigels, an emerging hybrid platform in transdermal drug delivery, which ingeniously integrates the penetrative efficiency of transferosomes with the sustained release capability of bigels. We delve into the detailed formulation processes, highlighting the physicochemical properties and the underlying mechanisms of action that confer these systems their unique transdermal delivery advantages. The review expansively covers a range of therapeutic applications, from chronic disease management to targeted drug delivery in cancer therapy, underscoring the versatility of transferosomal bigels. Through illustrative case studies, we demonstrate their potential in enhancing drug permeation, improving patient compliance, and minimizing systemic side effects. The paper also addresses the current challenges in the large-scale production and stability of these formulations, providing insights into future research directions. We emphasize the significant impact of transferosomal bigels in transforming transdermal drug delivery, pointing towards a future where non-invasive, efficient drug administration becomes a cornerstone of therapeutic strategies.