Primary documentation on the scientific study of glycemic variability indicators in children and adolescents with diabetes mellitus type 1 diabetes

The main purpose of creating an electronic database was to assess indicators of glycemic variability in adolescents and children diagnosed with diabetes mellitus type 1. The database presents the results of prospective, open, controlled, clinical study obtained over a period of one and a half years. Base data includes information on 307 patients (children and adolescents) aged 3 to 17 years inclusive. The observed patients were divided into two groups: Group 1 - patients diagnosed with type 1 diabetes mellitus and with diabetic complications, 152 people, Group 2 – patients diagnosed with type 1 diabetes mellitus and without diabetic complications, 155 people. All database registrants were assigned individual codes, which made it possible to exclude personal data (full name) from the database.

During the study, an analysis of carbohydrate metabolism was carried out with an assessment HbA1c (glycated hemoglobin), CGMS (continuous glucose monitoring), FMG (flash glucose monitoring) with face-to-face consultations with an endocrinologist and analysis of the data obtained. Obtained monitoring results were processed using a specialized variability calculator glycemia (EasyGV®, ver. 9), the following indicators and indices were calculated variability: average glycemic level (Mean), standard deviation (SD); index prolonged increase in glycemia (CONGA); glycemic lability index (LI); index risk of hypoglycemia (LBGI); hyperglycemia risk index (HBGI), average value overall risk (ADRR), average amplitude of glycemic fluctuations (MAGE); grade inter-day GV (MODD), rate of change in glycemia (MAG), J-index - indicator quality of glycemic control. The database is intended for entering, organizing, storing and displaying all of the above data.