AN OVERVIEW APPROPRIATE ADJUSTMENT FOR VANCOMYCIN LEVEL, COMPLICATIONS

Vancomycin is a glycopeptide antibiotic used to treat grampositive bacterial infections. Consumption has recently grown due to an increase in the incidence of infections caused by methicillinresistant S. aureus (MRSA). Increased use has been linked to increased minimum inhibitory concentration (MIC) levels, a phenomenon known as "MIC." Although the source of this creep is unknown, it has raised clinical concerns about the use of vancomycin. The emphasis on appropriate drug use has increased. Literature search done through the databases, for all published articles up to the beginning of 2022. This narrative literature review's findings strongly show that there is a link between vancomycin trough value and nephrotoxicity. Patients with vancomycin troughs larger than 15 mg/liter had a higher risk of nephrotoxicity than patients with troughs less than 15 mg/liter. Toxicity increased with therapy duration, with the highest rates found in critically sick patients who were in the ICU and receiving concomitant nephrotoxins.