Dataset related to article "Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high-volume cancer center"
Creators
- Bertuzzi, Alexia1
- Grimaudo, Maria Susanna2
- Laffi, Alice1
- Giordano, Laura1
- Gennaro, Nicolò3
- Cariboni, Umberto1
- Siracusano, Licia Vanessa1
- Quagliuolo, Vittorio1
- Colombo, Piergiuseppe2, 1
- D'Orazio, Federico1
- Renne, Salvatore Lorenzo2, 1
- Specchia, Cristina1
- Cananzi, Ferdinando2, 1
- Marrari, Andrea4
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Navarria, Pierina1
- Daolio, Primo Andrea5
- Bastoni, Stefano5
- Santoro, Armando2, 1
Description
This record contains raw data related to article "Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high-volume cancer center"
Abstract
Introduction: The aim of this retrospective study was to investigate the clinicopathological characteristics of AYA sarcomas and their clinical outcomes at a high-volume single center.
Methods: Demographic, clinicopathological data on the diagnosis, treatment and follow-up of all sarcoma patients aged 16-39 years (ys) observed at our Institute between January 2010 and December 2021 were retrospectively collected, including diagnostic (TTD) and treatment delay(TTT), clinical outcomes (OS and PFS), and late-treatment effects.
Results: We identified 228 AYA patients, median age 30 years, 29% ≤ 25 years, 57% males, 88% soft tissue sarcomas (STS), and 12% bone sarcomas (BS). Among STSs, 13% were small round cell tumors (SRCT), 52% intermediate-high-grade, 24% low-grade STSs. Among BS, 32% were high-grade. Median TTD and TTT were 120 (0-8255) and 7 days (0-83), respectively. Surgery was performed in 83%, radiotherapy in 29%, and systemic therapy in 27%. Median follow-up was 72.9 months(1.6-145), 5-year and 10-year OS were 78.5% and 62%, respectively. Kaplan-Meyer analysis showed a significantly better 5-year OS and PFS for patients with >92 days of TTD (OS 85.7% vs. 66.7%, p = 0.001, PFS 50.2% vs. 24.9%, p = 0.009). According to age (≤25 years vs. > 25 years), 5-year OS was 69.8% versus 82.2%, respectively (p = 0.047).
Conclusion: Our analysis confirmed previous data on sarcoma AYA patients followed in a referral center. Unexpectedly, diagnostic delay was not associated with poor OS and PFS. Patients <25 years showed a poorer prognosis due to the higher incidence of SRCT.
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- Publication: 10.1002/cam4.6289 (DOI)
- Publication: 37366268 (PMID)