COVID-19 infection and cold antibody autoimmune hemolytic anemia

Several case reports have implicated an association between COVID-19 infection and autoimmune hemolytic anemia, a known hematologic sequel of various infections. Given the complexity of the pathophysiologic relationship between SARS-Cov-2 infection and autoimmune hemolysis, the underlying mechanisms proposed so far have not yet been fully elucidated. Despite the still sparse case reports and possible underreporting, cold antibody hemolytic anemia in the setting of COVID-19 is of particular interest, with the number of its cases growing since the start of the pandemic.