Published June 30, 2023
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A case of Tuberous Sclerosis with Behavioral Problems and Poor Scholastic Performance
Description
Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous syndrome with variable and heterogeneous expression. Prevalence is of 1 in 6,000 newborns affecting both sexes equally. TSC1 and TSC2 genes are tumor-suppressor genes, either of which when lost causes formation of hamartomas. Although there has been great progress in the identification and treatment of many of the physical features, the neuropsychiatric manifestations remain highly under identified and undertreated.
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Additional details
Dates
- Accepted
-
2023-02-22
References
- 1. Sahin M. Tuberous Sclerosis. In: Kliegmann RM, Stanton BF, St Geme III JW, Schor NF, editors. Nelson textbook of Pediatrics, 20 th ed. 2016;3:2877-9. 2. Ashfaq F, Karki S, Ishfaq H et al. Tuberous sclerosis in a 16 years old female: A case report. Annals of Medicine and Surgery.2022 February; 74(103331): 1-4. 3. Saha R, Bhatia S, Doval N. Tuberous sclerosis complex with multiple psychiatric co-morbidities: a case report. Int J Health Sci Res. 2016;6(4):566-8. 4. de Vries PJ, Wilde L, de Vries MC, Moavero R, Pearson DA, Curatolo P. A clinical update on tuberous sclerosis complex-associated neuropsychiatric disorders (TAND) Am J Med Genet. 2018;178C:309–20. 5. Panwar PK, Chaudhary KP, Sharma K. Tuberous sclerosis. Delhi J Ophthalmol. 2014;24(3)192-4. 6. de Vries P. Neurodevelopmental, psychiatric and cognitive aspects of tuberous sclerosis complex. In: Kwiatkowsi DJ, Whittemore VH, Thiele EA, editors. Tuberous sclerosis complex. Weinheim: Wiley-Blackwell; 2010. pp. 229–68.