Published October 24, 2023 | Version v2
Dataset Open

CFdb: interactomes

  • 1. University of British Columbia

Description

This upload contains predicted interactomes for 23 species derived from meta-analysis of co-fractionation mass spectrometry (CF-MS) data. The following individual organisms are represented:

  • Arabidopsis thaliana
  • Brassica oleracea
  • Caenorhabditis elegans
  • Chaetomium thermophilum
  • Chlamydomonas reinhardtii
  • Dictyostelium discoideum
  • Drosophila melanogaster
  • Glycine max
  • Homo sapiens
  • Mus musculus
  • Nematostella vectensis
  • Oryza sativa
  • Plasmodium berghei
  • Plasmodium falciparum
  • Plasmodium knowlesi
  • Saccharomyces cerevisiae
  • Strongylocentrotus purpuratus
  • Triticum aestivum
  • Trypanosoma brucei
  • Xenopus laevis
  • Escherichia coli
  • Anabaena sp. PCC 7120
  • Synechocystis sp. PCC 6803

Network inference was performed by training a random forest classifier on known complexes (from CORUM or EcoCyc, for eukaryotes and prokaryotes respectively) to predict interacting protein pairs in cross-validation. Files include the complete classifier scores for every possible protein pair, sorted in descending order. The resulting networks can then be thresholded at an arbitrary precision.

Files

Files (3.1 GB)

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