FORMULATION AND CHARACTERIZATION OF ANTIFUNGAL NANOEMULSION OF KETOCONAZOLE

Nanoemulsions, also known as submicron emulsions, ultrafine emulsions and miniemulsions, are submicron sized colloidal particulate systems considered as thermodynamically and kinetically stable isotropic dispersions, which consist of two immiscible liquids like water and oil, stabilized by an interfacial film consisting of a suitable surfactant and co-surfactant to form a single phase. 

The goal is to develop and test a nanoemulsion of the antifungal drug ketoconazole. The next challenge was to demonstrate that the system can administer medicine over healthy skin more consistently and uniformly over a longer period of time than is feasible with nonoemulsion. The oil phase of coconut oil, Tween 80 surfactants, and ethanol cosurfactants were chosen as the constituents for the nanoemulsion formulation. The aqueous titration method was used to build pseudo-ternary phase diagrams. The phase diagram showed various oil and surfactant concentrations, and the resulting nanoemulsions were chosen based on the thermodynamic stability and dispersibility tests. Based on factors such as reduced viscosity, minimal polydispersity value, optimal globule size, greater drug release, and overall lower surfactant concentration and co-surfactant, the optimized formulation was chosen for an in vivo investigation. It was discovered that the nanoemulsion formulation's t max differed.

Keywords- Nanoemulsion, Microdomains