PREPARATION AND CHARACTERISATION OF MICROPARTICULATE DRUG DELIVERY SYSTEM OF DIACEREIN

The objective of the present study was to prepare and evaluate the floating microspheres of Diacerein. Diacerein microspheres were prepared by ionotropic gelation method using polymers such as HPMC (K 100 M), Carbopol, Ethyl cellulose and sodium alginate. Totally 12 different formulations of Diacerein were prepared by using the above polymers. The microspheres were characterized for entrapment efficiency, floating property by in vitro wash-off test and in-vitro drug release. Theformulation F9 was selected as an ideal formulation based on the in vitro release profile which shows an extended drug release of 95% upto 12 hours 0.1N HCl buffer. Surface morphology (SEM analysis) and drug-polymerinteraction studies (FT-IR analysis) were performed only for the ideal formulation, F9. The microspheres were discrete, spherical in shape and had ideal surface morphology as confirmed by SEM and FT-IR studies indicated the lack of drug-polymer interactions in the ideal formulation, F9. The in vitro release data of all microsphere formulations were plotted in various kinetic equations to understand the mechanisms and kinetics of drug release. The ideal formulation, F9 followed first order kinetics and value of "n," is calculated to be 0.7187 indicated that the drug release shows Non-Fickian diffusion.

Keywords

: HPMC (K 100 M), Carbopol, Ionotropic gelation method, Diacerein, Sodium Alginate, Ethyl Cellulose