Norwegian Journal of development of the International Science
Published October 12, 2023 | Version v1
Journal article Open

CHANGES IN THE BLOOD GLUCOSE AND SERUM LIPIDS IN MEN AGED 37 TO 45 YEARS WITH A TESTOSTERONE LEVEL BELOW THE AVERAGE VALUES OF THE STANDARD FOR A PROLONGED PERIOD

Creators

Description

Abstract

Introduction

In our study, we focused on a group of young men's with a testosterone level below the average values of the standard for a prolonged period and the changes in the blood glucose and serum lipids values.

Methods

From January 2013 to December 2019 at the Andrological office we examined 73 men aged 37 to 45 years with normal or elevated body mass index and a testosterone level below the average values of the standard for a prolonged period. We selected a control group of 20 age-matched men.

Results

In the patients, we obtained, although within reference limits, reliably lower values for total serum testosterone compared to those of the control group (p<0.001). We found significant differences in mean levels of blood glucose and serum lipids between the study men and those of the control group (p<0.001).

Conclusions

Our studies unequivocally show that even at a young age, some men, regardless of their BMI, have certain deviations in the normal secretion of testosterone. Along with that, changes in the blood glucose and serum lipids were observed, which, differed significantly from the same parameters in their peers with a high degree of normality the serum testosterone level. The changes we have found, probably (?) reversible with lifestyle changes, but if ignored can lead to metabolic syndrome at a later age.

Other

References:

  1. Cohen J, Nassau D, Patel P et al. Low testosterone in adolescents and young adults. Front Endokrinol, 2020; 10(1): 916-920. doi: 10.3389/fendo.2019.00916.
  2. Scovell J, Ramasamy R, Wilken N et al. Hypogonadal symptoms in young men are associated with a serum total testosterone threshold of 400 ng/dl. BJU Int, 2015; 116(1): 142-146. doi: 10.1111/bju.12970.
  3. Peterson M, Belakovskiy A, McGrath R et al. Testosterone deficiency Weakness and Multymorbidity in Men Sci Rep, 2018; 8(1): 1-9. doi: 10.1038/s41598-018-24347-6.
  4. Poobalan A. Aucott L.  Obesity among young adults in developing countries: a systemic overview. Curr Obes Rep, 2016; 5(1): 2-13. doi: 10.1007/s13679-016-0187-x.
  5. Ma J, Wang B, Li H еt al. Assotiation between obesity-associated markers and semen quality parameters and serum reproductive hormones in Chinese infertile men. Reprod Biol Endocrinol, 2020; 18(95): 351-359.
  6. Macdonald A, Stewart A, Farquhar C. Body mass index in relation to semen quality and reproductive hormones in New Zealand men: a cross sectional study in fertility clinics. Hum Reprod 2013; 28(12): 3178-3187. doi: 10.1093/humrep/det379.
  7. Pivonello R, Menafra D, Enrico Riccio E et al. Metabolic Disorders and Male Hypogonadotropic Hypogonadism Front Endocrinol, 2019 (10) doi.org/10.3389/fendo.2019.00345
  8. Salas-Huetos A, Maghsoumi-Norouzabad L, James E et al. Male adiposity, sperm parameters and reproductive hormones: an updated systemic review and collaborative meta-analysis. Obes Rev, 2021, 22(1): 154-162. doi: 10.1111/obr.13082.
  9. Wu F, Tajar A, Pye S et al. Hypotalamic-pituitary-testicular axis disruptions in older men are differentialy linked to age and modifiable risk factors: the Europen Male Aging Study. J Clin Endocinol Metab, 2008; 93(7): 2737-2745. doi: 10.1210/jc.2007-1972.
  10. Ferrando A, Sheffield-Moore M, Yeckel C et al. Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. Am J Physiol Endocrinol Metab, 2002; 282(3): 601–607.doi: 10.1152/ajpendo.00362.2001.
  11. Kenny A, Prestwood K, Gruman C et al. Effects of transdermal testosterone on lipids and vascular reactivity in older men with low bioavailable testosterone levels. J Gerontol A Biol Sci Med Sci, 2002; 57(7): 460–465. doi: 10.1093/gerona/57.7.m460.
  12. Page S, Amory J, Bowman F et al. Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab, 2005; 90(3): 1502–1510. doi: 10.1210/jc.2004-1933.
  13. Snyder P, Peachey H, Berlin J et al. Effect of transdermal testosterone treatment on serum lipid and apolipoprotein levels in men more than 65 years of age. Am J Med, 2001; 111(4): 255–260.doi: 10.1016/s0002-9343(01)00813-0.
  14. Chosich J, Bradford A, Allshouse A et al. Acute recapitulation of the hyperinsulinemia and hyperlipidaemia characteristic of metabolic syndrome suppresses gonadotropins. Obesity, 2017; 25(3): 553-60. doi: 10.1002/oby.21754.
  15. Kumanov Ph, Tomova A, Robeva R et al. Influence of ageing and some lifestyle factors on male gonadal function: a study in Bulgaria. Andrologia, 2007; 39(4): 136-140. doi: 10.1111/j.1439-0272.2007.00780.x.
  16. Mulligan T, Frick M, Zuraw M et al.  Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract, 2006; 60(7): 762–769. doi: 10.1111/j.1742-1241.2006.00992.x
  17. Zhong O, Lin J, Wang J et al. Association of diabetes and obesity with sperm parameters and testosterone levels: a meta-analysis. Diabetol Metab Syndr, 2021; 13(1): 109-113. doi: 10.1186/s13098-021-00728-2.
  18. Tsai E, Matsumoto A, Fujimoto W et al. Association of bioavailable, free and totaltestosterone with insulin resistance. Diabetes Care, 2004; 27(4): 861-868. doi: 10.2337/diacare.27.4.861.
  19. Levine H, Jorgensen N, Martino-Andrade A et al. Temporal trends in sperm count: a systemic revive and meta-regression analysis. Hum Reprod Update, 2017; 23(6): 646-659. doi: 10.1093/humupd/dmx022.
  20. Bhasin S, Buckwalter J. Testosterone supplementation in older men: a rational idea whose time has not yet come. J Androl, 2001; 22(5): 718-731.
  21. Harman S, Metter E, Tobin J et al. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab, 2001; 86(2): 724-731 doi: 10.1210/jcem.86.2.7219.
  22. Wang C, Nieschlag E, Swerdloff R et al.  Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur Urology, 2009; 55(1): 121-130. doi: 10.1530/EJE-08-0601
  23. Salonia A, Rastrelli G, Wilken N et al. Pediatric and adult onset hypogonadism. Nat Rev, 2019; 5(1): 1-21. doi: 10.1038/s41572-019-0087-y.

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