Published April 1, 2014
| Version v1
Journal article
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Interactions Between the Dietary Polyunsaturated Fatty Acid Ratio and Genetic Factors Determine Susceptibility to Pediatric Crohn's Disease
Description
Increased dietary ratios of u6/u3 polyunsaturated fatty
acids have been implicated in the pathogenesis of Crohn's
disease (CD), but epidemiologic data are limited. We
investigated whether variants of genes that control polyunsaturated
fatty acid metabolism (CYP4F3, FADS1, and
FADS2), along with the dietary ratio of u6/u3, confers
susceptibility to CD. Based on data from 182 children
newly diagnosed with CD and 250 controls, we found that
children who consumed a higher dietary ratio of u6/u3
were susceptible for CD if they were also carriers of specific
variants of CYP4F3 and FADS2 genes. Our findings
implicate diet–gene interactions in the pathogenesis of CD.
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