Published November 1, 2013
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Plasmodium falciparum mitochondrial genetic diversity exhibits isolation-by-distance patterns supporting a sub-Saharan African origin
Description
The geographical distribution of single nucleotide polymorphism (SNP) in the mitochondrial genome of the
human malaria parasite Plasmodium falciparum was investigated. We identified 88 SNPs in 516 isolates from
seven parasite populations in Africa, Southeast Asia and Oceania. Analysis of the SNPs postulated a sub-
Saharan African origin and recovered a strong negative correlation between within-population SNP diversity
and geographic distance from the putative African origin over Southeast Asia and Oceania. These results are
consistent with those previously obtained for nuclear genome-encoded housekeeping genes, indicating that
the pattern of inheritance does not substantially affect the geographical distribution of SNPs.
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