Published April 22, 2015 | Version v1
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Photo-organocatalytic Enantioselective Perfluoroalkylation of β-Ketoesters

  • 1. Institute of Chemical Research of Catalonia (ICIQ)

Description

The visible-light-driven, phase-transfer-catalyzed, enantioselective perfluoroalkylation and trifluoromethylation of cyclic β-ketoesters is described. The photo-organocatalytic process, which occurs at ambient temperature and under visible light illumination, is triggered by the photochemical activity of in situ-generated electron donor–acceptor complexes, arising from the association of chiral enolates and perfluoroalkyl iodides. Preliminary mechanistic studies are reported.

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