Journal article Open Access

Appendage Regeneration in Adult Vertebrates and Implications for Regenerative Medicine

Brockes, Jeremy P.; Kumar, Anoop

The regeneration of complex structures in adult salamanders depends on mechanisms that offer pointers for regenerative medicine. These include the plasticity of differentiated cells and the retention in regenerative cells of local cues such as positional identity. Limb regeneration proceeds by the local formation of a blastema, a growth zone of mesenchymal stem cells on the stump. The blastema can regenerate autonomously as a self-organizing system over variable linear dimensions. Here we consider the prospects for limb regeneration in mammals from this viewpoint.

Files (314.5 kB)
Name Size
article.pdf
md5:d1103d6636c43f2b95ab1af676c19442
314.5 kB Download
1,763
1
views
downloads
Views 1,763
Downloads 1
Data volume 314.5 kB
Unique views 1,314
Unique downloads 1

Share

Cite as