Published October 5, 2013
| Version v1
Journal article
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Regulation of pluripotency by general transcription factors
Creators
- 1. Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA
Contributors
Contact person:
- 1. Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA
Description
Transcription factor II D (TFIID) is a kind of general transcription factors, and plays critical role in transcription initiation by RNA polymerase II (Pol II). It is composed of TATA binding protein (TBP) and several TBP-associated factors (TAFs). Although its role in transcription is well studied, it is not clear whether it has tissue- or development-specific function. Pijnappel et al. identified the role of TFIID in the regulation of embryonic stem cell (ESC) identity, thereby enriching our understanding of the multifaceted functions of TFIID and also the mechanisms that govern ESC fate.
Notes
Editorial | Biohelikon : Cell Biology
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Additional details
Related works
- Is part of
- 2348-3741 (ISSN)