FGF-10 and FGF-21 mediated inflammation through LDLR in psoriasis plaques

In psoriasis, growth factors may also play a role in inflammation enhancement. Fibroblast growth factor (FGF)-10 and FGF21 are overexpressed and implicated in psoriasis pathogenesis. To postulate the association of FGF10 and FGF21 and transcripts expressed in psoriasis plaques, we analyzed RNA-seq from biopsied Uninvolved skin (UN skin) and center of plaque skin (CE skin) of patients with moderate to severe psoriasis vulgaris and showed different expression of genes (DEGs). FGF10 and FGF21 were the upstream regulators with positive activity z-score. Their shared downstream target gene in psoriasis plaques is LDLR. Upregulation of LDLR may eventually result in inflammatory response exacerbation. FGF21 regulator was involved in the upregulation of SOD2 in psoriatic plaques. Although SOD2 activity inhibited ROS production, SOD2 in psoriasis was dysfunctional, which might increase mtROS and progress in inflammation. Treatment that targets FGF10 and FGF21 might provide good outcomes in psoriatic patients.