Genetic architecture of cardiac dynamic flow volumes (GWAS summary statistics)

GWAS summary statistics (phenotype name given in the "phenotype" column: “iaorta_area” - BSA-indexed aortic area; “vmax”: peak forward aortic velocity; “vmax_adjusted” - peak forward aortic velocity adjusted to the aortic area; “vmin” - peak regurgitant aortic velocity; “imitral_regurgitation” - BSA-indexed mitral valve regurgitation volume; “ao_regurgitation_fraction” - aortic regurgitation fraction; “ao_regurgitation_volume” - aortic regurgitation volume; “tLVSV” - total left ventricular stroke volume; “netLVSV” - net left ventricular stroke volume; “fLVSV” - forward left ventricular stroke volume). “CHR”: chromosome of the SNV; “POS”: position; “MarkerID”: SNV ID, given either in rsID or chromosome:position:ref:alt; “Allele1”: the alternative allele; “Allele2”: the reference allele; “AC_Allele2”: allele count of the reference allele; “AF_Allele2”: allele frequency of the reference allele; “MissingRate”: proportion of missing or unobserved genotypes; “BETA”: effect size; “SE”: standard error; “Tstat” t-statistics; “var”: estimated variance component for the genetic effect; “p.value”: p-value; “q_value”: q-value after calculating the FDR using the Benjamini-Hochberg (BH) method concatenating all GWAS summary statistics per cluster (see Methods); “N”: sample size.

GWAS summary statistics tables of the sensitivity analysis per phenotype (phenotype name given in the filename: “iaorta_area” - BSA-indexed aortic area; “vmax”: peak forward aortic velocity; “vmin” - peak regurgitant aortic velocity; “imitral_regurgitation” - BSA-indexed mitral valve regurgitation volume; “ao_regurgitation_fraction” - aortic regurgitation fraction; “ao_regurgitation_volume” - aortic regurgitation volume; “netLVSV” - net left ventricular stroke volume; “fLVSV” - forward left ventricular stroke volume). “CHR”: chromosome of the SNV; “POS”: position; “MarkerID”: SNV ID, given either in rsID or chromosome:position:ref:alt; “Allele1”: the alternative allele; “Allele2”: the reference allele; “AC_Allele2”: allele count of the reference allele; “AF_Allele2”: allele frequency of the reference allele; “MissingRate”: proportion of missing or unobserved genotypes; “BETA”: effect size; “SE”: standard error; “Tstat” t-statistics; “var”: estimated variance component for the genetic effect; “p.value”: p-value; “N”: sample size.