Interaction of a nine steroid derivatives with aromatase enzyme surface using a theoretical model
Creators
- 1. Pharmacochemistry Laboratory at the Faculty of Biological Chemistry Sciences of the Autonomous University of Campeche, Av. Agustín Melgar s / n, Col Buenavista c.p. 24039 Campeche Cam., Mexico.
- 2. Faculty of Nutrition, Universidad Veracruzana. Medicos y odontologos s / n, c.p. 91010, Xalapa, Veracruz. Mexico.
Description
Some aromatase enzyme inhibitors drugs have been used to treat cancer; however, their interaction with aromatase is not clear. The aim of this study was to evaluate the possible interaction of nine steroid derivatives with aromatase enzyme surface using 3eqm protein, exemetane and formestene as theoretical tools in Docking Server program. The results showed differences in the aminoacid residues involved in the interaction of steroid derivatives (1-9) with 3eqm protein surface compared with exemetane and formestene. Besides, the inhibition constant for steroid derivatives 1, 2 and 5 was lower compared to exemetane and formestene drugs. In conclusion, the steroid derivatives 1, 2 and 5 could act as aromatase enzyme inhibitors and this phenomenon could be translated as good compounds to treat breast cancer.
Files
PJSE v.9 n.6 (14-19) Oct 1, 2023, Figueroa et. al.pdf
Files
(701.6 kB)
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