THE ROLE OF ENDOTHELIAL DYSFUNCTION IN PNEUMONIA IN PATIENTS WITH ISCHEMIC STROKE

In 78 patients with pneumonia (mean age 59±7 years), serum levels of endothelin-1 (ET-1) were determined. Of these, the first (main) group included 41 patients with pneumonia who had a history of ischemic stroke (IS) for more than six months (P+IS), the second group (comparison) consisted of 37 with pneumonia without a history of stroke (P). In patients with P+IS, compared with patients with P without a history of stroke, the symptoms of the disease were more pronounced due to a more severe course of pneumonia. In all patients, the content of serum ET-1 was significantly higher than the control values, more pronounced in patients with P+IS. Indicators of the content of ET-1 had correlations with the state of lung function. Thus, the course of the disease in patients with pneumonia is characterized by the development of endothelial dysfunction. Their intensity is more pronounced in patients with cardiovascular diseases, in particular with a history of IS.