Understanding The Role of Molecular Targeted Therapeutic Drugs In Non-Small Cell Lung Cancer (NSCLC): A Narrative Review

Worldwide the second most common cancer is lung cancer with tobacco as the main reason for the disease. Lung cancer is chiefly classified into small cell lung cancer and non-small cell lung cancer. Various genes that cause tumorigenesis in non-small cell lung cancer are linked to multiple pathways like ALK, MET, EGFR, and RET. Genomic profiling and mutational analysis in recent years have progressed the field of genetics of lung cancer substantially. In this present review, we converse about the various targeted therapeutic drugs and their advancement in treatment of non-small cell lung cancer (NSCLC). The present review scrutinize the existing documentation in the literature related to the targeted therapies of non-small cell lung cancer (NSCLC). English language articles were searched in various databases such as Pubmed, Scopus, Science direct and Google scholar. The keyword used for searching are “non-small cell lung cancer”, “Targeted therapy”, “Therapeutic drugs”.