fastBCR software

fastBCR is an efficient tool tailored for B cell receptor (BCR) clonal family inference, particularly from extensive BCR repertoire datasets. This tool contributes to advancing our comprehension of B cell activation and antibody-related investigations. Its primary objective is the prompt identification of B cell clonal families within vast BCR heavy chain sequences. To further bolster post-clustering analysis, fastBCR offers an array of functional modules. These include multiple sequence alignment (MSA), phylogenetic tree construction, somatic hypermutation (SHM) evaluation, and class switch analysis (CSR). Additionally, fastBCR incorporates a BCR simulation module that aids in generating variable B cell clonal lineages with distinct mutation rates. These modules enhance the applicability of fastBCR in BCR repertoire analysis and the exploration of antibodies, making it a valuable asset in immunological research. fastBCR is continuously updated and maintained on GitHub (https://github.com/ZhangLabTJU/fastBCR).