REVIEW OF FAST DISSOLVING TABLETS CONTAINING SOLID DISPERSION OF CYCLOSPORINE

The concept of solid dispersion was proposed by Sekiguchi and Obi in the early 1960’s, who investigated the generation and dissolution performance of eutectic, melts of a sulfonamide drug and water soluble carrier. Solid dispersion represents a useful pharmaceutical method for increasing the dissolution, absorption and therapeutic efficacy of the drug in the dosage forms.In present study was an attempt was made to develop fast dissolving tablets containing solid dispersion of Cyclosporine Cyclosporine by using PVP K30 as a carrier and crospovidone and croscarmellose  sodium as a  perdisintegrants. From data obtained from formulation and evaluation of dissolving tablet, following conclusions were made:.

Keywords: Solid Dispersion, Cyclosporine, Fusion method