Can Digital Mobility Assessment Enhance the Clinical Assessment of Disease Severity in Parkinson's Disease?
Creators
- 1. Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
- 2. Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK | Janssen Research & Development, High Wycombe, United Kingdom
- 3. chool of Allied Health (Exercise Science) / Health Futures Institute, Murdoch University, Perth, Australia
- 4. Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK | National Institute for Healthand Care Research (NIHR) Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK
- 5. Department of Statistical Science "Paolo Fortunati", University of Bologna, Bologna, Italy
- 6. Department of Electrical, Electronic and Information Engineering, "Guglielmo Marconi", University of Bologna, Bologna, Italy | Health Sciences and Technologies—Interdepartmental Center for Industrial Research (CIRI-SDV), University of Bologna, Bologna, Italy
- 7. ISGlobal, Barcelona, Spain | University Pompeu Fabra, Barcelona, Spain | CIBER Epidemiologica y Salud Publica (CIBERESP), Barcelona, Spain
- 8. Department of Neurology, Christian-Albrecht-University Kiel, Kiel, Germany
- 9. Department of Neurology, Christian-Albrecht-University Kiel, Kiel, Germany | German Centre of Neurodegenerative Diseases (DZNE), Tübingen, Germany
- 10. Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK |National Institute for Healthand Care Research (NIHR) Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK | Newcastle upon Tyne Hospitals NHS Foundations Trust, Newcastle upon Tyne, UK
Description
Abstract
Background:
Real-world walking speed (RWS) measured using wearable devices has the potential to complement the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS III) for motor assessment in Parkinson’s disease (PD).
Objective:
Explore cross-sectional and longitudinal differences in RWS between PD and older adults (OAs), and whether RWS was related to motor disease severity cross-sectionally, and if MDS-UPDRS III was related to RWS, longitudinally.
Methods:
88 PD and 111 OA participants from ICICLE-GAIT (UK) were included. RWS was evaluated using an accelerometer at four time points. RWS was aggregated within walking bout (WB) duration thresholds. Between-group-comparisons in RWS between PD and OAs were conducted cross-sectionally, and longitudinally with mixed effects models (MEMs). Cross-sectional association between RWS and MDS-UPDRS III was explored using linear regression, and longitudinal association explored with MEMs.
Results:
RWS was significantly lower in PD (1.04 m/s) in comparison to OAs (1.10 m/s) cross-sectionally. RWS significantly decreased over time for both cohorts and decline was more rapid in PD by 0.02 m/s per year. Significant negative relationship between RWS and the MDS-UPDRS III only existed at a specific WB threshold (30 to 60 s, β= – 3.94 points, p = 0.047). MDS-UPDRS III increased significantly by 1.84 points per year, which was not related to change in RWS.
Conclusion:
Digital mobility assessment of gait may add unique information to quantify disease progression remotely, but further validation in research and clinical settings is needed.
Notes
Files
2023_Kirk_PD_RWS_jpd--1-jpd230044.pdf
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