Published August 15, 2023 | Version v1
Journal article Open

Review of the Biological Activity of Rutin: Antidiabetic, Antioxidant, Anti-inflammatory and Antitumor

Creators

  • 1. Volgograd Medical State University

Description

Various parts of plants have long been widely used for the treatment and prevention of diseases. They are a valuable source of biologically active compounds, especially they are rich in polyphenolic structures. Rutin belongs to the group of some of the most common flavonoids in plant objects. Animal organisms do not have enzyme systems for its synthesis, so it enters the human body only with plant food. Rutin is widely used as a component in herbal medicines, multivitamin preparations, in the cosmetology, food and chemical industries. This article discusses the biological activity of rutin, namely antidiabetic, antioxidant, anti-inflammatory and antitumor activity. The article summarizes the current data on the above-mentioned types of biological activity. It follows from the presented research results that rutin is a promising compound with multi-target activity for the treatment of various diseases. It can serve as a basis for the creation of new highly effective pharmacological molecules based on it.

Files

93_05.pdf

Files (377.3 kB)

Name Size Download all
md5:59c5c9761c88c622071498fca84bb02d
377.3 kB Preview Download

Additional details

References

  • Koval'skii, I. V., Krasnyuk, I. I., Nikulina, O. I., Belyatskaya, A. V., Kharitonov, Yu. Ya., Fel'dman, N. B., & Lutsenko, S. V. (2014). Mekhanizmy farmakologicheskogo deistviya rutina (obzor). Khimiko-farmatsevticheskii zhurnal, 48(2), 3-6. (in Russian). https://doi.org/10.30906/0023-1134-2014-48-2-3-6
  • Chiryapkin, A. S., Zolotykh, D. S., & Pozdnyakov, D. I. (2023). Obzor biologicheskoi aktivnosti flavonoidov: kvertsetina i kempferola. Juvenis Scientia, 9(2), 5-20. (in Russian). https://doi.org/10.32415/jscientia_2023_9_2_5-20
  • Fernandes, A. A. H., Novelli, E. L. B., Okoshi, K., Okoshi, M. P., Di Muzio, B. P., Guimarães, J. F. C., & Junior, A. F. (2010). Influence of rutin treatment on biochemical alterations in experimental diabetes. Biomedicine & Pharmacotherapy, 64(3), 214-219. https://doi.org/10.1016/j.biopha.2009.08.007
  • Kamalakkannan, N., & Prince, P. S. M. (2006). Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin induced diabetic wistar rats. Basic & clinical pharmacology & toxicology, 98(1), 97-103. https://doi.org/10.1111/j.1742-7843.2006.pto_241.x
  • Vasta, J. D., Corona, C. R., Wilkinson, J., Zimprich, C. A., Hartnett, J. R., Ingold, M. R., ... & Robers M. B. (2018). Quantitative, wide-spectrum kinase profiling in live cells for assessing the effect of cellular ATP on target engagement. Cell chemical biology, 25(2), 206-214. https://doi.org/10.1016/j.chembiol.2017.10.010
  • Dubey, S., Ganeshpurkar, A., Ganeshpurkar, A., Bansal, D., & Dubey, N. (2017). Glycolytic enzyme inhibitory and antiglycation potential of rutin. Future Journal of Pharmaceutical Sciences, 3(2), 158-162. https://doi.org/10.1016/j.fjps.2017.05.005
  • Prince, P. S. M., & Kamalakkannan, N. (2006). Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes. Journal of biochemical and molecular toxicology, 20(2), 96-102. https://doi.org/10.1002/jbt.20117
  • Niture, N. T., Ansari, A. A., & Naik, S. R. (2014). Anti-hyperglycemic activity of rutin in streptozotocin-induced diabetic rats: an effect mediated through cytokines, antioxidants and lipid biomarkers. IJEB, 52(7). http://nopr.niscpr.res.in/handle/123456789/29045
  • Hao, H. H., Shao, Z. M., Tang, D. Q., Lu, Q., Chen, X., Yin, X. X., ... & Chen, H. (2012). Preventive effects of rutin on the development of experimental diabetic nephropathy in rats. Life sciences, 91(19-20), 959-967. https://doi.org/10.1016/j.lfs.2012.09.003
  • Cai, C., Cheng, W., Shi, T., Liao, Y., Zhou, M., & Liao, Z. (2023). Rutin alleviates colon lesions and regulates gut microbiota in diabetic mice. Scientific Reports, 13(1), 4897. https://doi.org/10.1038/s41598-023-31647-z
  • Tian, R., Yang, W., Xue, Q., Gao, L., Huo, J., Ren, D., & Chen, X. (2016). Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats. European journal of pharmacology, 771, 84-92. https://doi.org/10.1016/j.ejphar.2015.12.021
  • Yang, J., Guo, J., & Yuan, J. (2008). In vitro antioxidant properties of rutin. LWT-Food Science and Technology, 41(6), 1060-1066. https://doi.org/10.1016/j.lwt.2007.06.010
  • La Casa, C., Villegas, I., De La Lastra, C. A., Motilva, V., & Calero, M. M. (2000). Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. Journal of ethnopharmacology, 71(1-2), 45-53. https://doi.org/10.1016/S0378-8741(99)00174-9
  • Azevedo, M. I., Pereira, A. F., Nogueira, R. B., Rolim, F. E., Brito, G. A., Wong, D. V. T., ... & Vale, M. L. (2013). The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy. Molecular pain, 9, 1744-8069-9-53. https://doi.org/10.1186/1744-8069-9-53
  • Potapovich, A. I., & Kostyuk, V. A. (2003). Comparative study of antioxidant properties and cytoprotective activity of flavonoids. Biochemistry (Moscow), 68, 514-519. https://doi.org/10.1023/A:1023947424341
  • Kampkötter, A., Nkwonkam, C. G., Zurawski, R. F., Timpel, C., Chovolou, Y., Wätjen, W., & Kahl, R. (2007). Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. Toxicology, 234(1-2), 113-123. https://doi.org/10.1016/j.tox.2007.02.006
  • Al-Rejaie, S. S., Aleisa, A. M., Sayed-Ahmed, M. M., Al-Shabanah, O. A., Abuohashish, H. M., Ahmed, M. M., ... & Hafez, M. M. (2013). Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat. BMC complementary and alternative medicine, 13(1), 1-9. https://doi.org/10.1186/1472-6882-13-136
  • Yoo, H., Ku, S. K., Baek, Y. D., & Bae, J. S. (2014). Anti-inflammatory effects of rutin on HMGB1-induced inflammatory responses in vitro and in vivo. Inflammation Research, 63, 197-206. https://doi.org/10.1007/s00011-013-0689-x
  • Gautam, R., Singh, M., Gautam, S., Rawat, J. K., Saraf, S. A., & Kaithwas, G. (2016). Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects. BMC complementary and alternative medicine, 16(1), 1-6. https://doi.org/10.1186/s12906-016-1069-1
  • Selloum, L., Bouriche, H., Tigrine, C., & Boudoukha, C. (2003). Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation. Experimental and Toxicologic Pathology, 54(4), 313-318. https://doi.org/10.1078/0940-2993-00260
  • Nikfarjam, B.A., Adineh, M., Hajiali, F., & Nassiri-Asl, M. (2017). Treatment with Rutin - A Therapeutic Strategy for Neutrophil-Mediated Inflammatory and Autoimmune Diseases. Journal of Pharmacopuncture, 20, 52-56. https://doi.org/10.3831/KPI.2017.20.003
  • Abarikwu, S. O., Njoku, R. C. C., John, I. G., Amadi, B. A., Mgbudom-Okah, C. J., & Onuah, C. L. (2022). Antioxidant and anti-inflammatory protective effects of rutin and kolaviron against busulfan-induced testicular injuries in rats. Systems Biology in Reproductive Medicine, 68(2), 151-161. https://doi.org/10.1080/19396368.2021.1989727
  • Ganeshpurkar, A., & Saluja, A. (2020). Immunomodulatory effect of rutin, catechin, and hesperidin on macrophage function. Indian Journal of Biochemistry and Biophysics (IJBB), 57(1), 58-63. https://doi.org/10.56042/ijbb.v57i1.31775
  • Pan, P. H., Lin, S. Y., Wang, Y. Y., Chen, W. Y., Chuang, Y. H., Wu, C. C., & Chen, C. J. (2014). Protective effects of rutin on liver injury induced by biliary obstruction in rats. Free Radical Biology and Medicine, 73, 106-116. https://doi.org/10.1016/j.freeradbiomed.2014.05.001
  • Huang, F. M., Chang, Y. C., Lee, M. W., Su, N. Y., Yang, L. C., & Kuan, Y. H. (2023). Rutin alleviates bisphenol Aglycidyl methacrylate‐induced generation of proinflammatory mediators through the MAPK and NF/κB pathways in macrophages. Environmental Toxicology, 38(3), 628-634. https://doi.org/10.1002/tox.23711
  • Jayameena, P., Sivakumari, K., Ashok, K., & Rajesh, S. (2018). Rutin: A potential anticancer drug against human colon cancer (HCT116) cells. Int. J. Biol. Pharm. Allied Sci, 7(9), 1731-1745. https://doi.org/10.31032/IJBPAS/2018/7.9.4532
  • Saleh, A., ElFayoumi, H. M., Youns, M., & Barakat, W. (2019). Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions. Naunyn-Schmiedeberg's archives of pharmacology, 392, 165-175. https://doi.org/10.1007/s00210-018-1579-0
  • Nasiri, F., Kismali, G., Alpay, M., Kosova, F., Cakir, D. U., & Sel, T. (2016). Rutin enhances the antiproliferative effect of 5-FU and oxaliplatin in colon cancer cells. Cancer Research, 76(14), 2177-2177. https://doi.org/10.1158/1538-7445.AM2016-2177
  • Park, M. H., Kim, S., Song, Y. R., Kim, S., Kim, H. J., Na, H. S., & Chung, J. (2016). Rutin induces autophagy in cancer cells. International Journal of Oral Biology, 41(1), 45-51. https://doi.org/10.11620/IJOB.2016.41.1.045
  • Singh, T. A., Sadhukhan, P., Ghosh, N., Thakur, N., Sharma, A., Tejwan, N., ... & Sil, P. C. (2023). Targeted delivery of rutin into breast cancer cells via using phenylboronic acid functionalized MgO nanoparticles. Materials Science and Engineering, 296,. 116623. https://doi.org/10.1016/j.mseb.2023.116623
  • Lin, J. P., Yang,,J. S., Lin, J. J., Lai, K. C., Lu, H. F., Ma, C. Y., ... & Chung, J. G. (2012). Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo. Environmental toxicology, 27(8), 480-484. https://doi.org/10.1002/tox.20662
  • Khan, F., Pandey, P., Upadhyay, T. K., Jafri, A., Jha, N. K., Mishra, R., & Singh, V. (2020). Anti-cancerous effect of rutin against HPV-C33A cervical cancer cells via G0/G1 cell cycle arrest and apoptotic induction. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders), 20(3), 409-418. https://doi.org/10.2174/1871530319666190806122257