REVIEW OF SOLID LIPID NANOPARTICLES BASED NANOGEL FOR DERMAL DELIVERY OF INDOMETHACIN

Nanogels composed of Nano size particles formed by physically or chemically cross linked polymer networks that swells in a good solvent. The nanogel systems have proven their potential to deliver drugs in controlled, constant and targetable mode. With the promising field of polymer sciences it has now become predestinated to prepare smart nano-system which can establish effectual for treatment, diagnosing as well as clinical trials progress.Nanogels is been proving as a promising drug delivery system and offers variety of characteristics like on site drug delivery system, sustained release formulation, high drug entrapment properties, water solubility, biodegradability, low toxicity etc. Due to these multi functionality properties and features nanogel utilized extensively in many drug deliver fields. Composite with polymers, metals and other active molecules nanogel turned out as excellent drug delivery system.Although, Indomethacin possesses some favorable properties for topical administration like low molecular weight, low daily therapeutic dose yet, the inherent poor aqueous solubility and high melting point make it unsuitable for topical application. It does not exhibit enough lipophilicity for permeation across the skin. A number of topical/transdermal drug delivery systems, which vary in their compositions and structures have been developed to improve the skin permeation of Indomethacin. However, the poor drug loading capacity, poor drug controlled and sustained release capacities have limited their use as topical/transdermal carriers. The level of interest in lipid-based carrier systems have increased substantially for topical administration of drugs because of the use of fats and oils of natural origin and pharmaceutically accepted surfactant as excipients.

Keywords: Solid Lipid Nanoparticles, Nanogel, Freeze drying.