People's Journal of Scientific Research
Published June 1, 2019 | Version v1
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Sputum Bacterial Spectrum and Predominant Inflammatory Cells in Acute Exacerbations of COPD

Creators

  • 1. Department of Pulmonary Medicine, People's College of Medical Sciences and Research Centre, Bhopal

Description

This study was done to observe variation with seasons in sputum bacterial profile and predominant inflammatory 
cells  in  patients  with  AECOPD.  Hundred  sputum  samples  were  cultured  for  bacteria  and  examined  for  type  of 
inflammatory cells. Predominant bacteria and inflammatory cells and their variation with seasons were noted. Thirty six 
percent of sputum samples had bacterial growth. Bacterial growth was higher in summer and monsoon (43.3%) than in 
post- monsoon and winter period (21.2%) (p=0.031). Overall, Pseudomonas aeruginosa was the commonest organism 
cultured. In summer and post-monsoon, the commonest bacterium was Pseudomonas aeruginosa (16.6% and 15.4% 
respectively) and in monsoon, it was Klebsiella species (19.3%). Sputum neutrophilia (N>61%) was seen in 91% and 
sputum  eosinophilia  (E>3%)  in  41%  of  the  samples.  There  was  no  significant  difference  in  the  predominant 
inflammatory cells (N and N+ E) in sputum with seasons. Isolated sputum eosinophilia was higher in post- monsoon and 
winter than in summer and monsoon (12.1% v/s 7.5%, p=0.021). Length of hospital stay was less in patients with sputum 
eosinophilia  than  in  patients  with  sputum  neutrophilia  (9.11v/s  10.12  days,  p=0.023).  Sputum  neutrophilia  was 
associated with higher sputum bacterial isolation. Eosinophilia in the sputum was likely to be associated with a sterile 
sputum. Bacterial isolation was higher in summer and monsoon than post- monsoon and winter. There was no significant 
difference  in  the  predominant  inflammatory  cells  with  seasons.  Sputum  eosinophilia  was  associated  with    faster 
recovery from AECOPD than sputum neutrophilia.

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References

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