SCimilarity Models

SCimilarity is a unifying representation of single-cell expression profiles that quantifies similarity between expression states and generalizes to represent new studies without additional training. This enables a novel cell search capability, which sifts through millions of profiles to find cells similar to a query cell state and allows researchers to quickly and systematically leverage massive public scRNA-seq atlases to learn about a cell state of interest.

This repository includes model weights, embeddings, kNN graphs, and metadata for the SCimilarity cell search model in two components:

• Annotation model components - Files required for the CellAnnotation methods.
• Query model components - Files required for the CellQuery methods.