Published October 31, 2022
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Fig. 10. Compound 4 induced HepG2 cells apoptosis. HepG2 in Artemidubolides A T, cytotoxic unreported guaiane-type sesquiterpenoid dimers against three hepatoma cell lines from Artemisia dubia
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- 1. * & State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, & * & University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China
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Fig. 10. Compound 4 induced HepG2 cells apoptosis. HepG2 cells were treated with different concentrations (0.0, 3.5, 7.0, and 10.5 μM) of 4 for 48 h. (A) and (B) Flow cytometric analysis and cell apoptosis quantification of HepG2 cells. (C) and (D) The apoptosis-related protein levels in hepatoma cells treated with compound 4 for 48 h. Western blot and statistical results of Bax, BCL-2, PARP-1, and cleaved-PARP-1. The results were normalized to the β-actin loading control. *P <0.05, **P <0.01, and ***P <0.001, n = 3.
Notes
Published as part of Gao, Zhen, Ma, Wen-Jing, Li, Tian-Ze, Ma, Yun-Bao, Hu, Jing, Huang, Xiao-Yan, Geng, Chang-An, He, Xiao-Feng, Zhang, Xue-Mei & Chen, Ji-Jun, 2022, Artemidubolides A T, cytotoxic unreported guaiane-type sesquiterpenoid dimers against three hepatoma cell lines from Artemisia dubia, pp. 1-17 in Phytochemistry (113299) 202 on page 14, DOI: 10.1016/j.phytochem.2022.113299, http://zenodo.org/record/8237057
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- Journal article: 10.1016/j.phytochem.2022.113299 (DOI)
- Journal article: urn:lsid:plazi.org:pub:F75EFFF12B1FFFE1FFE1FF83FFB5FFB3 (LSID)
- Journal article: https://zenodo.org/record/8237057 (URL)