hannenhalli-lab/Epigenetic_Project: Epigenetic Project

In this study, we have analysed epigenomic mark H3K27Ac mark distribution pre epigenetic drug treatment in two different cell lines i.e. HCT116 and RH4. Based on change in gene expression after epigenetic drug treatment, we identified 1000 up and 1000 downregulated genes. For these genes, we analyse the pre-treatment H3K27Ac marks across 21 genomic bins. These bins were created using Promoter (10 bins), TSS and Gene Body (10 bins).

Next, we developed machine learning model for predicting given the pre-treatment transcriptome and epigenomic profile of a sample, the extent to which one can predict locus-specific changes in gene expression upon treatment with HDACi.